Carbon Nanotubes for Biomedical Applications
Rüdiger Klingeler, Robert B. Sim
Springer Science & Business Media, Feb 9, 2011 - Technology & Engineering - 278 pages
This book explores the potential of multi-functional carbon nanotubes for biomedical applications. It combines contributions from chemistry, physics, biology, engineering, and medicine. The complete overview of the state-of-the-art addresses different synthesis and biofunctionalisation routes and shows the structural and magnetic properties of nanotubes relevant to biomedical applications. Particular emphasis is put on the interaction of carbon nanotubes with biological environments, i.e. toxicity, biocompatibility, cellular uptake, intracellular distribution, interaction with the immune system and environmental impact. The insertion of NMR-active substances allows diagnostic usage as markers and sensors, e.g. for imaging and contactless local temperature sensing. The potential of nanotubes for therapeutic applications is highlighted by studies on chemotherapeutic drug filling and release, targeting and magnetic hyperthermia studies for anti-cancer treatment at the cellular level.
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Part II Magnetically Functionalised Carbon Nanotubes for Medical Diagnosis and Therapy
Part III Interaction with Biological Systems
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acid activation antibodies anticancer drug aqueous binding biocompatibility biodistribution biological biomedical applications cancer cells carboplatin catalyst cellular Chem chemical cisplatin CNT-CP CNTs complement complement system complexes conjugates contrast agents covalent cytotoxicity diameter dispersion doxorubicin drug delivery DWCNTs e-CNT effect electrical electron encapsulated Fe-cat-MWCNT Fe-MWCNTs ferrocene ferromagnetic filled MWCNT filling yield fluorescence fullerenes functionalisation functionalized carbon nanotubes gene human hyperthermia incubated inside interaction iron nanowire Klingeler lung macrophages magnetic field magnetic properties magnetic resonance magnetisation material mechanism membrane metallic method mice microscopy molecular molecules multi-walled carbon nanotubes MWCNT Nano Lett nanomaterials Nanomedicine nanoparticles nanoscale Nanotechnol Nanotechnology nanowires NMR spectroscopy non-covalent nuclear oxide particles pathway peptides Phys polymer potential proteins Raman receptors sample sensors signal single-walled carbon nanotubes solution SP-A structure surfactant SWCNTs synthesis targeting temperature therapeutic therapy tissue toxicity treatment tubes tumor uptake vectors vitro vivo walled carbon nanotubes