Carcinogenicity: Testing: Predicting, and Interpreting Chemical Effects

Front Cover
CRC Press, Oct 29, 1998 - Science - 920 pages
Offers comprehensive coverage of currently available cancer predictors, the most recent research on carcinogenicity, and the design and interpretation of carcinogenicity experiments. Presents mouse, rat, and human carcinogenicity data for the liver, kidney, breast, cervix, prostate, hematopoietic system, colon, skin, urinary bladder, mouth, stomach, thyroid, and pancreas.
 

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Contents

Value Validity and Historical Development of Carcinogenesis
21
Predicting Carcinogenicity
117
The Maximum Tolerated Dose and Secondary Mechanisms
125
Mouse Liver Carcinogenesis
145
Information Sources on the Carcinogenicity of Chemicals
197
Use of Mutagenicity for Predicting Carcinogenicity
209
The
227
The k Test
251
Forestomach and Glandular Stomach Carcinogenesis
467
Thyroid Carcinogenesis
499
Organs with High Animal
531
Mammary Cancer
563
Cancers of the Hematopoietic System in Rodents
581
Urinary Bladder Cancer
627
Cancers of the Oral Cavity
653
Reactive Intermediates and Skin Cancer
679

Gap Junctional Intercellular Communication as a Method
267
Predicting Chemical Carcinogenicity by In Vivo
289
Liver Pyruvate Kinase as a Predictor of Promotion
319
Peroxisome Proliferators
337
The Rat Liver HepatocellularAltered FocusLimited
361
Transgenic Animals as Predictive Models
395
Human Liver Carcinogenesis
411
Comparative Kidney Carcinogenesis in Laboratory Rodents
439
Organs with Low Animal
715
Exocrine Pancreatic Cancer
747
Colorectal Cancer
787
Cervix Uteri and Uterus Cancer
799
Summary of All Organs
837
1
847
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