Cardiac Electrophysiology, Circulation, and Transport

Front Cover
S. Sideman, Rafael Beyar, Andre G. Kleber
Springer Science & Business Media, Apr 30, 1991 - Medical - 387 pages
The cardiac system represents one of the most exciting challenges to human ingenuity. Critical to our survival, it consists of a tantalizing array of interacting phenomena, from ionic microscopic transport, membrane channels and receptors through cellular metabolism, energy production to fiber mechanics, microcirculation, electrical activation to the global, clinically observed, function, which is measured by pressure, volume, coronary flow, heart rate, shape changes and responds to imposed loads and pharmaceutical challenges. It is a complex interdisciplinary system requiring the joint efforts of the life sciences, the exact sciences, engineering and technology to understand and control the pathologies involved. The Henry Goldberg Workshops were set up to address these challenges. Briefly, our goals are: 1. To foster interdisciplinary interaction between scientists from different areas of cardiology, identify missing links, and catalyze new questions. 2. To relate micro scale cellular phenomena to the global, clinically manifested cardiac function. 3. To relate conceptual modeling and quantitative analysis to experimental and clinical data. 4. To encourage international cooperation so as to disperse medical and technological know how and lead to better understanding of the cardiac system. Today we celebrate the 7th birthday of a dream come true; a dream to bring together the diversified expertise in the various fields of science, engineering and medicine, to relate to the numerous interactive parameters and disciplines involved in the performance of the heart.
 

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Contents

A CELLULAR ACTIVATION MODEL BASED ON MACROSCOPIC FIELDS
3
MODELING OF CELLULAR AND INTERCELLULAR PROPAGATION
13
ANISOTROPIC CONDUCTION AND INHOMOGENEITY IN REFRACTORINESS
29
DIFFERENT MECHANISMS FOR REENTRY IN THE EPICARDIAL BORDER ZONE OF HEALING CANINE INFARCTS THE ROLES OF FUNC...
37
EFFECTS OF INTERCELLULAR RESISTIVE COUPLING ON ACTION POTENTIAL INITIATION
47
REENTRY OF CARDIAC EXCITATION A SIMULATION STUDY
63
CONDUCTION VELOCITY VARIABILITY IN THE ISCHEMIC MYOCARDIUM AS THE CAUSE OF REENTRANT ARRHYTHMIAS
73
Propagation of the Cardiac Impulse
81
THE CONTROL OF CARDIAC ADENINE NUCLEOTIDES THE DISCOVERY AND POTENTIAL FUNCTION OF HIGHENERGY OLIGOMERIC ...
205
ON THE CONTRACTILE MECHANISM IN CARDIAC MUSCLE
215
Myocardial Mechanics
227
MODELING THE EFFECT OF CONTRACTILITY ON DISTRIBUTION OF CORONARY FLOW
229
INTRAMYOCARDIAL PRESSURE REVISITED
237
ON THE MECHANISM OF TRANSMURAL MYOCARDIAL COMPRESSION AND PERFUSION
245
Circulation and Coronary Flow
259
A MODEL FOR DISTURBED CORONARY ARTERY FLOW WITH PHONOCARDIOGRAPHIC VERIFICATION
261

DETERMINANTS OF ACTION POTENTIAL TRANSFER FROM CELL TO CELL
83
THE EFFECT OF THE FINITE EXTRACELLULAR RESISTANCE ON IMPULSE CONDUCTION IN THE VENTRICULAR MYOCARDIUM
91
THE EFFECTS OF POTASSIUM ON ANISOTROPIC CONDUCTION
101
EFFECT OF RYANODINE AND OTHER MODULATORS OF INTRACELLULAR CALCIUM ON IMPULSE PROPAGATION DURING SIMULAT...
109
LOW DIMENSIONAL CHAOS AND THE TRANSITION FROM RHYTHMIC TO ARRHYTHMIC BEHAVIOR IN CARDIAC TISSUE
115
FRACTAL MECHANISMS IN CARDIAC ELECTROPHYSIOLOGY
125
Cell Physiology and Pathophysiology
135
CARDIAC SODIUM CHANNEL KINETICS
137
REGULATION OF CATIONIC FLUX THROUGH CARDIAC SARCOPLASMIC RETICULUM
145
VOLTAGE CLAMP TESTS OF A MODEL OF CALCIUM HANDLING BY MYOCARDIAL CELLS
155
MODULATION OF VENTRICULAR IMPULSE INITIATION AND REPOLARIZATION BY SYMPATHETIC INNERVATION
169
RELATING MEMBRANE RECEPTORS TO DRUGS
179
EXCITATIONCONTRACTION COUPLING IN STUNNED MYOCARDIUM
185
BIOCHEMICAL MECHANISMS CONTRIBUTING TO ARRHYTHMOGENESIS DURING ISCHEMIA
195
LEFT VENTRICULAR PRESSURE VERSUS CONTRACTILITY AS CAUSES FOR PULSATILE CORONARY FLOW
273
ARE FLOW TRANSPORT CAPACITIES AND METABOLIC REQUIREMENTS MATCHED REGIONALLY IN THE MYOCARDIUM?
281
DIMINISHED TOLERANCE TO ISCHEMIA OF HYPERTROPHIED HEARTS
295
CAPILLARY GROWTH IN NORMAL AND HYPERTROPHIC HEART
307
Myocardial Metabolism and Energetics
317
MYOCARDIAL BLOOD FLOW AND OXIDATIVE METABOLISM FINDINGS IN NORMAL AND DISEASED MYOCARDIUM
319
OXIDATIVE SUBSTRATE METABOLISM IN REPERFUSED MYOCARDIUM
333
THE ROLE OF DRIVING FORCES IN MYOCARDIAL ENERGY METABOLISM AND TRANSPORT PROCESSES
341
THE EFFECT OF EXOGENOUS LACTATE AND PYRUVATE ON TRIACYLGLYCEROL TURNOVER IN THE NORMOXIC HEART
351
General Discussion
363
GENERAL DISCUSSION
365
INDEX
377
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