Cardiac Electrophysiology Methods and Models
Daniel C. Sigg, Paul A. Iaizzo, Yong-Fu Xiao, Bin He
Springer Science & Business Media, Sep 11, 2010 - Medical - 492 pages
Cardiovascular disease is the major cause of mortality and morbidity in the Western Hemisphere. While significant progress has been made in treating a major sub-category of cardiac disease, arrhythmias, significant unmet needs remain. In particular, every day, thousands of patients die because of arrhythmias in the US alone, and atrial fibrillation is the most common arrhythmia affecting millions of patients in the US alone at a given time. Therefore, there is a public need to continue to develop new and better therapies for arrhythmias. Accordingly, an ever increasing number of biomedical, pharmaceutical, and medical personnel is interested in studying various aspects of arrhythmias at a basic, translational, and applied level, both in industry (ie Biotech, Pharmaceutical and device), and in academia. Not only has our overall understanding of molecular bases of disease dramatically increased, but so has the number of available and emerging molecular, pharmacological or device treatment based therapies. This practical, state-of-the art handbook will summarize and review key research methods and protocols, their advantages and pitfalls, with a focus on practical implementation, and collaborative cross-functional research. The volume will include visual and easy-to-use graphics, bulleted summaries, boxed summary paragraphs, links to reference websites, equipment manufacturers where appropriate, photographs of typical experimental setups and so forth, to keep this book very focused on practical methods and implementation, and yet, provide enough theory that the principles are clearly understood and can be easily applied.
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Part I Overview
Part II Methods and Models
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action potential anatomy animal models antibody artery atrial fibrillation atrioventricular atrioventricular node block bundle branch Ca2+ calcium cardiac arrhythmias cardiac electrophysiology cardiac tissue cardiomyocytes Cardiovasc Electrophysiol catheter ablation cellular Circ Res Circulation clinical complex conduction system connexin coronary sinus culture defibrillation depolarization developed disease drug electroanatomical mapping electrocardiogram electrode electrograms endocardial epicardial excitation experimental fiber fluorescence function gap junction gene heart failure heart model human imaging implantable infarction intracardiac intracellular ion channels isolated lead left atrium left ventricular mechanisms membrane potential method microelectrode muscle myocardial myocardium neonatal optical mapping pacemaker pacing patch clamp pathway patients perfusion Physiol physiological procedure propagation proteins pulmonary vein recording reentry refractory rhythm right atrium right ventricular signal sinoatrial sinoatrial node sodium channel solution specific Springer Science+Business Media stimulation surgical syndrome tachyarrhythmias techniques therapy tion typically valve ventricle ventricular myocytes ventricular tachycardia vitro voltage