Cardiac Tissue Engineering

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Morgan & Claypool Publishers, 2012 - Technology & Engineering - 200 pages
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Cardiac tissue engineering aims at repairing damaged heart muscle and producing human cardiac tissues for application in drug toxicity studies. This book offers a comprehensive overview of the cardiac tissue engineering strategies, including presenting and discussing the various concepts in use, research directions and applications. Essential basic information on the major components in cardiac tissue engineering, namely cell sources and biomaterials, is firstly presented to the readers, followed by a detailed description of their implementation in different strategies, broadly divided to cellular and acellular ones. In cellular approaches, the biomaterials are used to increase cell retention after implantation or as scaffolds when bioengineering the cardiac patch, in vitro. In acellular approaches, the biomaterials are used as ECM replacement for damaged cardiac ECM after MI, or, in combination with growth factors, the biomaterials assume an additional function as a depot for prolonged factor activity for the effective recruitment of repairing cells. The book also presents technological innovations aimed to improve the quality of the cardiac patches, such as bioreactor applications, stimulation patterns and prevascularization. This book could be of interest not only from an educational perspective (i.e. for graduate students), but also for researchers and medical professionals, to offer them fresh views on novel and powerful treatment strategies. We hope that the reader will find a broad spectrum of ideas and possibilities described in this book both interesting and convincing. Table of Contents: Introduction / The Heart---Structure, Cardiovascular Diseases, and Regeneration / Cell Sources for Cardiac Tissue Engineering / Biomaterials -- Polymers, Scaffolds, and Basic Design Criteria / Biomaterials as Vehicles for Stem Cell Delivery and Retention in the Infarct / Bioengineering of Cardiac Patches, \textit {In Vitro / Perfusion Bioreactors and Stimulation Patterns in Cardiac Tissue Engineering / Vascularization of Cardiac Patches / Acellular Biomaterials for Cardiac Repair / Biomaterial-based Controlled Delivery of Bioactive Molecules for Myocardial Regeneration
 

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Contents

Introduction
1
The HeartStructure Cardiovascular Diseases and Regeneration
7
Cell Sources for Cardiac Tissue Engineering
27
Biomaterials Polymers Scaffolds and Basic Design Criteria
41
Biomaterials as Vehicles for Stem Cell Delivery and Retention in the Infarct
55
Bioengineering of Cardiac Patches In Vitro
63
Perfusion Bioreactors and Stimulation Patterns in Cardiac Tissue Engineering
87
Vascularization of Cardiac Patches
109
Acellular Biomaterials for Cardiac Repair
117
Biomaterialbased Controlled Delivery of Bioactive Molecules for Myocardial Regeneration
143
Authors Biographies
183
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