Cardiac Energetics: From Emax to Pressure-Volume Area
Martin M. LeWinter, Hiroyuki Suga, Matthew W. Watkins
Springer US, Oct 31, 1995 - Medical - 240 pages
Most of the progress in cardiac energetics in recent years has been spurred by the pressure-volume area concept, the natural extension into energetics of earlier pioneering work delineating the time-varying elastance framework for ventricular contraction. The book draws together a broad spectrum of researchers - basic, applied and clinical - having a shared interest in the energetics of cardiac muscle and ventricle, providing an overview of the current state of the art.
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Constancy and Variability
Thin Filament Regulation and Cardiac Energetics
Explaining LoadDependent Ventricular Performance
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02 cost actin activation adrenoceptors aequorin afterload angiotensin arterial pressure baroreflex Ca++ ions Ca++ transients calcium calcium transient canine left ventricle cardiac muscle catheter changes Circ Circ Res constant contractile efficiency contraction coronary correlation cost of PVA crossbridge crossbridge cycling cyclic AMP decreased dobutamine Ea/Ees ejection elastance Emax end-diastolic volume Endoh energetics ESPVR Fenn effect force function Goto heart failure heart rate hydrolysis increase inotropic agents inotropic effect intracellular isolated isometric isoproterenol isovolumic left ventricle left ventricular loading conditions LV volume measured mechanical efficiency mechanically unloaded metabolism milrinone myocardial oxygen consumption myocardium myofilaments nonmechanical optimal oxygen papillary muscle patients perfused permission from ref Pharmacol Physiol positive inotropic preload pressure-volume area proteins rabbit ratio receptors regional myocardial regional V02 Reprinted with permission slope stimulation subendocardial Suga systolic thin filament troponin ventriculo-arterial coupling VH and VL wall