Cardiomyopathies and Heart Failure: Biomolecular, Infectious and Immune Mechanisms

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Akira Matsumori
Springer Science & Business Media, Jul 31, 2003 - Medical - 531 pages
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Heart failure is a major, cause of death worldwide, most frequently secondary toacardiomyopathicdisorder. The rolesofviruses, immunity, cytokines and genetics as sources of heart failure have been relatively understated in the rapidly developing world of clinical cardiology. Yet, great progress in molecular biology and the recent application of new techniquesto studiesoftheetiologyandpathogenesisofcardiomyopathies and heart failure has shed new light in an area ready to undergo major developmentsandadvances. This book is an effort to present an up-to-date account of eXIstmg knowledge, includingrecentdevelopmentsinthisfield. Chapterscovering severaldisciplinesincludingbiochemistry, immunology, molecularbiology, virology, epidemiologyandclinicalmedicinehavebeenincluded, offeringa "bench-to-bedside"and"bedside-to-bench"criticalreviewofeveryaspects of heart failure and cardiomyopathies, by world renowned, expert researchers and clinicians. These opinion leaders review all significant advances in our understandingofheart failure and cardiomyopathies, and describe theimprovements indiagnosis and treatment that areexpectedto optimize the overall management of patients. The identification of establishedornewlyrecognizedmolecules, cytokines, viruses, andgenes, as well as an understandingofthe mechanisms by which these factors may cause cardiomyopathic disorders and induce heart failure depends on a multidisciplinaryapproachwhichthisbookattemptstouniquelyencompass. Therefore, wehopethatitwillbeanimportantresource, notonlyforclinical cardiologists, butalso forgeneralpractitioners, pediatriciansandspecialists in infectious diseases, as well as trainees and graduates in biochemistry, immunology, genetics, molecular biology, virology, pharmacology, and epidemiology. AkiraMatsumori, MD, PhD Ie INTRODUCTORYCHAPTER CARDIOMYOPATHIESANDHEARTFAILURE Biomolecular, InfectiousandImmuneMechanisms AkiraMatsumori, MD, PhD DepartmentofCardiovascularMedicine KyotoUniversityGraduateSchoolofMedicine Kyoto, Japan 1 SUMMARY Theclinicalpresentationofviralmyocarditisisvariable. Whenmyocardial necrosis is diffuse, congestive heart failure develops, and later, dilated cardiomyopathy. If the myocardial lesions are localized, a ventricular aneurysmforms. Whencomplicatedbyarrhythmias, myocarditispresentsas arrhythmogenic right ventricular cardiomyopathy. When myocardial necrosisislocalizedtothesubendocardialregion, restrictivecardiomyopathy may develop. While it has not been established that hypertrophic cardiomyopathy maybeacomplicationofviral myocarditis, asymmetrical septal hypertrophy has, in fact, sometimesbeen observed in patients with myocarditis. TheimportanceofhepatitisCvirusinfectionhasrecentlybeen notedinpatientswithmyocarditis, dilatedandhypertrophiccardiomyopathy.
 

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Contents

INTRODUCTORY CHAPTER
1
CYTOKINES IN CARDIOMYOPATHIES
17
NEGATIVE REGULATOR OF CYTOKINE SIGNALING
27
THE INTERLEUKIN6 FAMILY OF CYTOKINES
39
ANIMAL MODEL OF CARDIOMYOPATHY DUE
47
MYOSIN AUTOREACTIVE T CELLS AND AUTOIMMUNE
59
AUTOIMMUNITY IN CARDIOMYOPATHIES
67
ANTIGPROTEIN COUPLED CARDIAC RECEPTOR
83
DETECTION AND BIOLOGICAL IMPLICATIONS
259
THE GROUP B COXSACKIEVIRUSES AS VACCINES
277
DETECTION OF IMPORTANT DIAGNOSTIC MARKERS
291
DIAGNOSIS AND TREATMENT OF MYOCARDITIS
301
HEPATITIS C VIRUS AND CARDIOMYOPATHY
325
CLINICAL DIAGNOSIS OF MYOCARDITIS
373
RECENT ADVANCES IN GIANT CELL MYOCARDITIS
389
REGISTRY OF MYOCARDITIS AND HEART FAILURE
401

CLINICAL SIGNIFICANCE OF CIRCULATING CARDIAC
97
MAST CELL MEDIATORS AND HUMAN
111
MAST CELLS IN EXPERIMENTAL MYOCARDIAL
121
POSSIBLE INVOLVEMENT OF MAST CELLS IN
133
HUMAN MAST CELL CHYMASE AND 31 AMINO ACID
145
TRYPTASE FROM HUMAN MAST CELLS
159
EFFECTS OF THE TRYPTASE RECEPTOR ACTIVATING
173
MAST CELL MEDIATORS AND HUMAN
185
MAST CELLS IN ATHEROSCLEROTIC HUMAN
199
THE KEY ROLE OF MAST CELLS IN THE EVOLUTION
213
LINKS BETWEEN VIRAL INFECTIONS AND HEART
229
MOLECULAR DETECTION AND CHARACTERIZATION
245
MOLECULAR AND GENETIC ANALYSES
415
GENEBASED THERAPY OF LONG QT SYNDROME
429
THE FUTURE IN THE MANAGEMENT
439
PROTECTION OF CELL INJURY BY THIOREDOXIN
457
HEMATOPOIETIC STEM CELLS AND ANGIOGENESIS
469
TRANSPLANTING CELLS FOR THE TREATMENT
481
TOWARD AN IDEAL LARGE ANIMAL MODEL
491
35 YEARS OF PROGRESS
503
GENES OF THE MAJOR HISTOCOMPABILITY COMPLEX
515
INDEX
523
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