Elsevier, 2008 - Medical - 437 pages
In 1993, Rolf Bodmer described a gene he named tinman that was required for the formation of the dorsal aorta of the fly. Flies without a functional tinman gene had no heart. Quickly, mammalian counterparts of the tinman gene were identified and found to be expressed by early cardiomyogenic precursors and by cardiomyocytes throughout heart development. Since then, significant progress has been made in the understanding of molecular and genetic determinants of heart formation. An ever growing number of genes have been identified that are required for cardiogenesis, as evidenced by severe abnormalities in cardiac development produced by inactivation in the mouse or inhibition of gene function in other model organisms.
Cardiovascular Development covers some of the latest research in the study of heart formation. Volume Editor Rolf Bodmer has assembled a world-class list of contributors whose research uses a variety of animal models and whose findings are certain to enhance our understanding of this exciting field.
* Ties together the development of heart morphology and conduction system
* The latest developments in vertebrate and invertebrate genetic model systems
* Technological advancements in cardiovascular science
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Morphogenesis of the Vertebrate Heart
Heart Development and Tbox Transcription Factors Lessons from Avian Embryos
Transcriptional Control of Cardiac Boundary Formation
Signaling Pathways in Embryonic Heart Induction
Islet1 Progenitors in Developing and Postnatal Heart
Role of microRNAs in Cardiovascular Biology
Divergent Roles of Hedgehog and Fibroblast Growth Factor Signaling in LeftRight Development
Development of the Conduction System Picking up the Pace
Transcriptional Control of the Cardiac Conduction System
Genetic Dissection of Hematopoiesis Using Drosophila as a Model System
Vascular Development in the Zebrafish
Development and Function of the Epicardium
Genetics of Transcription Factor Mutations
Human Genetics of Congenital Heart Disease
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activation adult aorta aortic arterial asymmetric atrial septal defect atrioventricular Biol blood Bodmer Bruneau bundle cardiac conduction system cardiogenesis Cardiol cardiomyocytes Cardiovasc cardiovascular chamber chick Christoffels congenital heart coronary developing heart developmental differentiation disease dorsal Drosophila early embryos endoderm endothelial epicardial epicardium FGF8 formation function gastrulation GATA4 gene expression Genes Dev Genet heart development heart field heart tube hematopoietic hemocytes Holt-Oram syndrome homeobox identified induce interactions Isl1 lineage lymph gland markers mesoderm mice microRNAs midline miRNAs molecular morphogenesis mouse embryo muscle mutations myocardial cells myocardium myocytes Natl neural crest Nodal node Notch signaling outflow tract pacemaker patterning phenotype primary myocardium proliferation protein pulmonary Purkinje receptor region regulation role signaling pathways specification stem cells stenosis studies suggesting syndrome T-box T-box genes target Tbx1 Tbx2 Tbx3 Tbx5 tinman tion tissue transcription factor valve vascular ventricle ventricular vertebrate vessels Xenopus Yutzey zebrafish