Cardiovascular Development

Front Cover
Rolf Bodmer
Elsevier, 2008 - Medical - 437 pages
0 Reviews
In 1993, Rolf Bodmer described a gene he named tinman that was required for the formation of the dorsal aorta of the fly. Flies without a functional tinman gene had no heart. Quickly, mammalian counterparts of the tinman gene were identified and found to be expressed by early cardiomyogenic precursors and by cardiomyocytes throughout heart development. Since then, significant progress has been made in the understanding of molecular and genetic determinants of heart formation. An ever growing number of genes have been identified that are required for cardiogenesis, as evidenced by severe abnormalities in cardiac development produced by inactivation in the mouse or inhibition of gene function in other model organisms.

Cardiovascular Development covers some of the latest research in the study of heart formation. Volume Editor Rolf Bodmer has assembled a world-class list of contributors whose research uses a variety of animal models and whose findings are certain to enhance our understanding of this exciting field.

* Ties together the development of heart morphology and conduction system
* The latest developments in vertebrate and invertebrate genetic model systems
* Technological advancements in cardiovascular science
 

What people are saying - Write a review

We haven't found any reviews in the usual places.

Contents

Morphogenesis of the Vertebrate Heart
31
Heart Development and Tbox Transcription Factors Lessons from Avian Embryos
69
Transcriptional Control of Cardiac Boundary Formation
93
Signaling Pathways in Embryonic Heart Induction
117
Islet1 Progenitors in Developing and Postnatal Heart
153
Role of microRNAs in Cardiovascular Biology
167
Divergent Roles of Hedgehog and Fibroblast Growth Factor Signaling in LeftRight Development
179
Development of the Conduction System Picking up the Pace
203
Transcriptional Control of the Cardiac Conduction System
219
Genetic Dissection of Hematopoiesis Using Drosophila as a Model System
259
Vascular Development in the Zebrafish
301
Development and Function of the Epicardium
333
Genetics of Transcription Factor Mutations
359
Human Genetics of Congenital Heart Disease
379
Index
419
Copyright

Other editions - View all

Common terms and phrases

About the author (2008)

Paul M. Wassarman, the Series Editor of CTDB since 2007, is Professor in the Dept. Developmental and Regenerative Biology at the Icahn School of Medicine at Mount Sinai in New York City. He received a Ph.D. in biochemistry from Brandeis University where he carried out thesis research in the Graduate Dept. Biochemistry with Professor Nathan O. Kaplan. In 1967 Wassarman joined the Division of Structural Studies at the MRC, Laboratory of Molecular Biology in Cambridge, England as a Helen Hay Whitney Foundation Fellow with Sir John C. Kendrew. In 1972 he joined the faculty of the Dept. Biological Chemistry at Harvard Medical School and in 1986 moved to the Roche Institute of Molecular Biology where he was Chair of the Dept. Cell and Developmental Biology and Adjunct Professor in the Dept. Cell Biology, New York University School of Medicine. In 1996 he moved to the Icahn School of Medicine at Mount Sinai where he was the Lillian and Henry M. Stratton Professorial Chair of the Dept. Molecular, Cell, and Developmental Biology. Wassarman has published more than 200 research papers and reviews, dealing primarily with mammalian oogenesis, fertilization, and early embryogenesis.

Bibliographic information