Cardiovascular Regeneration Therapies Using Tissue Engineering Approaches

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Hidezo Mori, Hikaru Matsuda
Springer Science & Business Media, Jun 18, 2006 - Medical - 238 pages
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The cardiovascular system transports oxygen and nutrients to all parts of the body; therefore, any impediment to this system through, for example, a circulatory disorder, represents a serious threat to organs, tissues, and cells. Obstructive diseases of vessels with a diameter of more than 1 mm can be treated by conventional surgical and interventional approaches; however, blockages in small vessels with a diameter of less than 1 mm cannot be treated by conventional methods. As a consequence, therapeutic ang- genesis and vasculogenesis for the treatment of ischemic diseases have been widely studied in the last decade. These methods may contribute to the re pair of intractable cardiovascular diseases with a main vascular involvement in the body's smallest vessels. In this book, Hikaru Matsuda and I have tried to summarize recent Japanese developments in the field of cardiovascular regeneration therapies using tissue engineering. The Ministry of Health, Labor, and Welfare of Japan has been encouraging the National Cardiovascular Center Research Institute to promote cardiovascular regeneration therapies using such ap proaches. Therefore, it is with the financial aid and support of research grants, such as that for Cardiovascular Disease (13C-1 and I6C-6), Health and Labor Sciences Research Grants (RHGTEFB-genome-005, RHGTEFB-saisei-003, and CRCD-junkanki-009) and a grant from NEDO of Japan, that significant progress has been possible.
 

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Contents

EPC and Their Potentiation by Adenovirus Gene Delivery
3
Potentiation of Regenerative Therapy by NonViral Vector Gelatin
17
Iwakura Atsushi 145
22
Regeneration of Myocardium Using Bone Marrow Cells
31
Cell Sheet Technology for Myocardial Tissue Engineering
44
Matsumura Goki 105
53
Cardiovascular Cell Differentiation from ES Cells
67
Preparation and Recellularization of Tissue Engineered Bioscaffold
82
Basic Fibroblast Growth Factor and Angiogenesis
145
The Role of Vascular Endothelial Growth Factor VEGF
173
A Novel MicroAngiography Detecting Angiogenesis
191
Angiogenesis Induced by Intramyocardial Implantation
200
Effect of Bone Marrow Transplantation in Patients with Critical
213
Therapeutic Angiogenesis for a Patient with Arteriosclerosis
221
Autologous Bone Marrow Implantation for Burgers Disease
228
Closing Remarks
234

Biotube Technology for a Novel TissueEngineered Blood Vessels
95
Vascular Regeneration and Remodeling by Circulating Progenitor Cells
115

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