Cardiovascular Soft Tissue Mechanics

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Stephen C. Cowin, Jay D. Humphrey
Springer Science & Business Media, 2001 - Mathematics - 246 pages
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The seven papers of this volume present a glimpse into current research on soft tissue mechanics as well as some future directions. The seven papers concern tissues within the cardiovascular system: three focus on arteries, three on the heart, and one on biaxial testing of planar tissues such as heart valves. Given that cardiovascular disease continues to be the leading cause of death in the developed world, the importance of such research is clear. There are notable common features of the seven papers. First, most of the proposed constitutive relations are motivated directly by data on the underlying microstructure, and especially the orientations of a structurally important protein (collagen) that forms as undulated cross-linked fibers. Another feature of most of the papers is the consideration of the fact that both arteries and the heart contain muscle and that there is a need to quantify the so-called active (contractile) response in addition to the passive (non-contractile) response. Such relations must not only be structurally motivated, they must ultimately include the kinetics of calcium transport in the muscle. Constitutive relations for active behavior are discussed in the majority of the papers. The growth and remodeling of cardiovascular tissues is another common feature of the papers. Over the last twenty years, separate advances in biochemistry, cell biology, genetic engineering, and biomechanics have focused attention on the ubiquitous role of growth and remodeling of tissues. This volume should be of interest to cardiovascular researchers in particular, and to bioengineers and biomechanics soft tissue researchers in general.
 

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Contents

HUMPHREY and P B CANHAM Structure Mechanical Proper
49
ALEXANDER RACHEV A Model of Arterial Adaptation to Alter
83
P NASH and P J HUNTER Computational Mechanics of
113
T P USYK R MAZHARI and A D McCULLOCH Effect of Lami
141
LARRY A TABER and RENATO PERUCCHIO Modeling Heart
165
MICHAEL S SACKS Biaxial Mechanical Evaluation of Planar Bio
199
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Texas A&M University