Cardiovascular Biology of Purines
Geoffrey Burnstock, James G. Dobson Jr., Bruce T. Liang
Springer US, Oct 31, 1998 - Medical - 374 pages
Following many years when a great deal of attention was directed towards the intracellular roles of purines, there is expanding interest in the field of extracellular purinergic signalling. In this book we focus on the actions of purines in cardiovascular biology, where it is clear that they play major roles in both normal and pathophysiological conditions. Activation of different purinoceptor subtypes by purines can regulate cardiac contractility and electrical activity, modulate catecholamine-mediated responses both pre- and post-junctionally, trigger and mediate ischaemic preconditioning, cause vasodilation and vasoconstriction and enhance endothelial proliferation and apoptosis as well as inhibit platelet and neutrophil function. This book covers the cardiovascular actions mediated by the major P1 and P2 subclasses of purinoceptors and emphasizes the interactions between these two signalling systems.
Cardiovascular Biology of Purines covers topics ranging from molecular and cellular to systemic and clinical. It also aims to highlight how basic advances have led to the identification of novel targets for cardiovascular therapeutic developments. We hope that our book will prove to be timely and helpful.
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A1 receptor action of adenosine adenine adenine nucleotides adenosine kinase adenosine receptor adenosine release adenylyl cyclase afferent neurons aged hearts agonist antiadrenergic atrial Belardinelli Biochem Burnstock G calcium cardiomyocytes cardioprotective Cardiovasc cardiovascular channel Circ Res cloned Cronstein Dobson JG effects of adenosine endogenous endothelial cells endothelium enzyme expression extracellular ATP Fenton RA function G protein guinea pig Harden TK human hearts hypoxia increase inhibition inhibitor inotropic intrinsic cardiac neurons ischemia ischemic isolated isoproterenol KATP mammalian mast cells mechanism mediated membrane metabolism modulation molecular mRNA myocardial myocardium nerves neutrophil nitric oxide nonfailing noradrenaline nucleotides P2X purinoceptors P2Y receptors pathway perfused Pharmacol pharmacological phospholipase Physiol platelets potential PPADS preconditioning protein-coupled purine purinergic receptors rabbit rat heart receptor agonists receptor subtypes regulation reperfusion role selective sensory neurites signaling smooth muscle cells stimulation studies subunits suramin sympathetic tachycardia tissue transgenic vascular smooth muscle vasodilation ventricular myocytes