Cardiovascular Specific Gene Expression
P.A.F.M. Doevendans, Robert S. Reneman, Marc van Bilsen
Springer, Apr 30, 1999 - Medical - 327 pages
Improving our insights into the genetic predisposition to cardiovascular disease is one of the most important challenges in our field in the next millennium, not only to unravel the cause of disease but also to improve the selection of patients for particular treatments. Nowadays, for example, subjects with a cholesterol above a particular plasma level are exposed to a cholesterol lowering regime based upon the beneficial outcome of epidemiological studies which include subjects not prone to the disease, despite a plasma cholesterol above the accepted level. Identification of the patients who are genetically predisposed to the consequences of this disorder will reduce the number of subjects unnecessarily treated and, hence, the costs of health care. Because in most cardiovascular diseases the genetic component is a consequence of more than one gene defect, only limited progress has as yet been made in identifying subjects genetically at risk. For example, in hypertension only in less than 10% of the patients the genetic defect has been identified. It has been known for quite some time that in heart and blood vessels fetal genes are as high blood pressure and upregulated or induced when they are exposed to such disorders ischemia. Little is known about the function of these genes in the cardiac and vascular adaptation to these disorders; only guesses can be made.
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A cardiacspecific troponin I promoter Distinctive patterns of regulation
Regulation of endothelial cell specific receptor tyrosine kinase gene expression
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Acad Sci USA Ad-MLCLuc adenoviral adult analysis angiogenesis antisense aorta arrhythmias arteries atrial binding Biol Chem blood vessels cardiac troponin cardiomyocytes cardiomyopathy cardiovascular cDNA cellular Circ Res clones cultured deficient detected differentiation disease embryonic endothelial cells endothelial growth factor estrogen exon extracellular fatty acids figure formation function gap junction gene expression genetic genomic heart human hybridization hypertensive hypertrophy IGF-II induced inhibition injection ischemia isoforms KvLQT1 levels ligand liver long QT syndrome luciferase luciferase activity membrane molecular mouse mRNA mutations myocardial myocardium myocytes Natl Acad Sci neonatal pathway pericytes phenotype plasmid plasminogen potassium channel Proc Natl Acad promoter protein receptor tyrosine kinase recombinant region regulation renin ribozyme role sequence SERCA signaling skeletal muscle SMCs smooth muscle cells smoothelin subunit syndrome target TIE2 tissue transcription factors transfected transgenic transgenic mice troponin uptake vascular endothelial growth vasculogenesis VEGF VEGF-A ventricle ventricular vitro vivo