Care of the Patient with Hepatitis C Virus Infection, An Issue of Infectious Disease Clinics
Hepatitis C infection can be an acute or chronic illness and is the most common cause of liver disease in the US. It often goes undiagnosed until significant organ damage has occurred. This issue of the ID Clinics discusses the staging of liver disease, treatments for those newly diagnosed, and those who are dealing with chronic illness, along with managing drug therapy and virus resistance.
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Staging of Liver Disease
Approach to the TreatmentExperienced Patient with
Managing Adverse Effects of InterferonAlfa
Future prospects forDAAsin HIVHCV coinfection Future Classes of Hepatitis C Virus Therapeutic Agents
Hepatitis CVirusDrug Resistance
Diagnosis andTreatment ofAcute Hepatitis CVirus Infection
12 weeks 24 weeks 48 weeks algorithm anemia antiretroviral antiviral therapy associated boceprevir chronic HCV chronic hepatitis cirrhosis cirrhotic clearance clinical cohort coinfected coinfected patients combination therapy Cvirus cyclophilin decompensation direct-acting antivirals discontinuation dose Engl etal FibroScan Gastroenterol Gastroenterology genotype 1 infection HCV genotype HCV infection HCV therapy hepatic encephalopathy hepatitis C virus hepatitisC hepatocellular carcinoma Hepatol Hepatology HIV/HCV IL28B genotype increased inthe IU/mL J.G. McHutchison lead-in liver biopsy liver disease liver fibrosis liver transplantation monotherapy noninvasive NS5A NS5B null responders ofthe patients with chronic patients with cirrhosis patientswith PEG-IFN Peg-IFN/RBV PegIFN/ribavirin Peginterferon alfa-2b pegylated pegylated interferon phase polymerase polymorphisms predict predictor regimens replication resistant variants ribavirin side effects significant fibrosis sustained virologic response SVR rates telaprevir tests treated treatment duration treatment response treatment-experienced patients treatment-naive patients trial triple therapy varices viral kinetics viral load virus HCV virus infection