Carnitine: The Science Behind a Conditionally Essential Nutrient, Volume 1033

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Salvatore Alesci
New York Academy of Sciences, 2004 - Medical - 199 pages
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Carnitine is a naturally occurring compound with a central role in intermediate metabolism. This nutrient is widely used as a dietary supplement for its actions on fat metabolism, muscle performance, and cognitive function. Several commercials promote its use by athletes and to combat obesity and aging without dose- or side-effect specifications, an issue of obvious public health relevance. Approved medical indications for carnitine supplementation include primary (systemic or myopathic) carnitine deficiencies and secondary depletion states observed in organic acidemias, beta-oxidation, and respiratory chain defects and in chronic renal and heart failure. Recent basic and clinical research supports a variety of beneficial effects of carnitine on the cardiovascular, immune, and nervous systems, on insulin resistance and obesity, apoptosis, and cancer. disease; in the lipodystrophy and neuropathy of HIV patients; in cancer-cachexia; in neurodegenerative disorders and the chronic fatigue syndrome; and in fertility, pregnancy, and premature neonates all show a wide range of potential applications for this natural nutrient, but have often led to contradictory results and

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Structure and Function of Carnitine Acyltransferases By GERWALD JOGL
Kinetics Pharmacokinetics and Regulation of LCarnitine
Carnitine Deficiency Disorders in Children By CHARLES A STANLEY

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