IARC Working Group on the Evaluation of Cancer-preventive Agents, International Agency for Research on Cancer
IARC, 1998 - Medical - 326 pages
The objective of the Handbooks program is the preparation of critical reviews and evaluations of evidence on the cancer-preventive and other relevant properties of a wide range of potential cancer-preventive agents and strategies by international working groups of experts.
In this volume on carotenoids their chemical and physical characteristics, occurrence, production, use, analysis and human exposure, metabolism, kinetics and genetic variation are studied, as well as their cancer-preventive effects, other beneficial effects, carcinogenicity and other toxic effects. A summary of data and recommendations for research are provided at the end.
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List of Participants
Chemical and physical characteristics of carotenoids
Metabolism kinetics and genetic variation
Other beneficial effects
Other toxic effects
Summary of data
The concept of activity profiles of mutagenicity
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aberrant crypt activity analysis animals antimutagenicity antioxidant astaxanthin azoxymethane basal diet beta-carotene body weight breast cancer buccal pouch cancer-preventive canthaxanthin carcinogenesis Carcinogens carcinomas carotene carotenoids case-control study CD CD CD cells colon concentrations of P-carotene controls cryptoxanthin dietary DMBA Edited effects Epidemiol etal evaluation experimental exposure f test female foci given P-carotene Group noted group receiving hamsters high dose human incidence inhibited injection intake intestinal inverse association ISBN 92 isomers Krinsky lipid liver lung cancer lutein lycopene male Mathews-Roth metabolism mg/d mg/kg bw mg/kg P-carotene mice mouse mutagenicity mutation Nutr oral oxidation P-carotene P-carotene concentrations P-cryptoxanthin patients placebo placebo beadlets plasma pmol/plate pouch tumours prevention Quartil rats reduced relative risk retinol retinyl palmitate serum significant significantly skin tumours smoking Student's f test Table tion tissue tocopherol treatment trials tumours unsupplemented versus vitamin vitro Volume weeks old women zeaxanthin