Casarett and Doull's Toxicology: The Basic Science of Poisons
Louis J. Casarett, Curtis D. Klaassen, Mary O. Amdur, John Doull
McGraw-Hill, Health Professions Division, 1996 - Medical - 1111 pages
Thoroughly updated & revised, this fifth edition delineates the basic concepts & fundamental principles needed to grasp current issues in modern toxicology. As in previous editions, the book successfully balances its encyclopedic coverage with a basic, fundamental, mechanistic approach to toxicology. The text is organized & presented in a logical progression of general principles to specific topics such as organ system toxicology, specific agent toxicology, & environmental toxicology.
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Principles of Toxicology
Mechanisms of Toxicity
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acetaminophen acid activity acute adducts aflatoxin agents alterations amines amino aneuploidy animals antibody antigen apoptosis aromatic assays axon bile binding Biochem biotransformation blood Ca2+ cancer carbon carcinogenesis carcinogenic catalyzed cause cells cellular chemical chromosome chronic compounds concentration conjugation cytochrome P450 cytokines damage decreased developmental toxicity disease dose drugs effects endothelial enzymes ethanol example excretion exposure factors formation function gene genetic glutathione hepatic hepatocytes hepatotoxicity human immune increase induced inhibition injury intracellular involved kidney lesions levels lipid liver lung macrophages mammalian mechanisms membrane metabolism metabolites methemoglobin mice microsomes molecular molecules mouse mutagens nephrotoxicity neurons occur organic oxidative oxygen P450 enzymes percent phenobarbital plasma potential produce proliferation protein proximal tubule pulmonary rats reactions reactive receptor renal repair response result risk assessment role species studies substrate synthesis target teratogenic Teratology tion tissue toxicity Toxicol Appl Pharmacol toxicology transport tubule tumor tumor suppressor genes vascular vitro vivo xenobiotics