Catalysis in Chemistry and EnzymologyExceptionally clear, carefully written treatment of the nature of catalysis of reactions in aqueous solution. Coverage of mechanisms for catalysis, forces in aqueous solution, carbonyl- and acyl-group reactions, practical kinetics, and much more. Extensive bibliography. "... a masterpiece."—Nature. |
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language is tougher and not east to nderstand and their are a lot of contradictions.
Contents
The Appendix has its own table of contents see pp 615616 | 1 |
Approximation 7 | 7 |
Chapter | 9 |
Chapter 3 | 27 |
Chapter 10 | 59 |
Chapter 6 | 81 |
General AcidBase Catalysis | 163 |
The Brønsted Relationship | 178 |
DonorAcceptor and Charge Transfer Interactions | 437 |
Related Phenomena and Long Electrondeficient Bonds | 449 |
Charge Transfer and DonorAcceptor Interactions in Biochemistry | 459 |
Tetrahedral intermediates and the ratedetermining step | 467 |
Change in ratedetermining step with changing concentra | 474 |
Change in ratedetermining step with changing structure | 480 |
Partitioning of an intermediate after the ratedetermining | 487 |
DoO and HC3 | 501 |
Isotope Effects | 243 |
Equilibria in Water and Deuterium Oxide | 250 |
Steric effects | 257 |
Nonlinear transition states | 263 |
Some Elementary Conclusions Regarding Deuterium Isotope | 273 |
Isotope effects on the Michaelis constant | 279 |
Manifestation of Enzymatic Specificity in Maximum Welocities | 288 |
FORCES IN AQUEOUs solution | 321 |
Electrostatic Interactions | 351 |
Concentrated salt solutions | 358 |
Explanations | 364 |
Concentrated salt solutions | 375 |
Hydrophobic Forces | 393 |
rºom and HOR | 508 |
RCSR and HOR | 517 |
RCSR and H N R | 537 |
Practical Kinetics | 555 |
The endpoint | 561 |
The Utilization of Pseudo Firstorder Rate Constants | 568 |
Effect of pH and ionization of the reactants | 577 |
Salt and solvent effects | 585 |
teadystate Rate Equations | 597 |
Thermodynamic activation parameters | 605 |
Summary of rules for intepretation | 612 |
| 823 | |
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Common terms and phrases
acceptor acetate acid catalysis acid-base catalysis active acyl addition aldehyde amines anion aqueous solution attack base catalysis basicity Biol Brønsted buffer carbon atom carbonyl group catalyzed reaction Chem chymotrypsin complex compounds concentration covalent decarboxylation decrease deuterium oxide diffusion-controlled electron enol entropy enzymatic reactions enzyme ester example formation free energy give hydration hydrogen bonding hydrolysis hydroxide ion hydroxyl group imidazole increase interaction intermediate intramolecular reactions involves kinetic leaving group mechanism of equation methyl nitrogen atom nucleophilic nucleophilic reactivity nucleophilic reagent observed occur oxygen atom p-nitrophenyl phenyl phosphate protein proton transfer pyridoxal R. P. Bell rate acceleration rate constant rate law rate-determining step reactants reacting salts Schiff base shown in equation solvated proton solvation solvent specific stabilization starting material steric structure substituted substrate T. C. Bruice thiol tion transfer reactions transition undergo W. P. Jencks zero-point energy
References to this book
Bibliographic information
| Title | Catalysis in Chemistry and Enzymology Dover books on physics and chemistry McGraw-Hill series in advanced chemistry |
| Author | William P. Jencks |
| Edition | illustrated, reprint, revised |
| Publisher | Courier Corporation, 1987 |
| ISBN | 0486654605, 9780486654607 |
| Length | 836 pages |
| Subjects | › › Science / Chemistry / General |
| Export Citation | BiBTeX EndNote RefMan |