There has been an enormous advance in our understanding of the regulation of the cell division cycle in the last five years. The leap in understanding has centered on the cell cycle control protein p34cdc2 and its congeners and on the cyclins. The most important insight to emerge has been that cell cycle control mechanisms and their participating proteins are very well-conserved through evolution. This has created a spectacular growth in knowledge as data from one organism have been readily applied to another. In this volume, there are sea urchin and frog eggs, as well as mammalian cells and yeast. There is also an illustration of how fruitful the genetic approach can be in other organisms than yeast with a chapter on Aspergillus nidulans.
The cell cycle kinase has been well-characterized and has also been well-exposed in numerous proceedings volumes and collections. In this issue of Advances in Molecular Cell Biology, the cell cycle kinase is ever present, but in the early chapters it has a supporting role. Center stage are the regulatory mechanisms that control the kinase. The contribution that the centrosome (the organelle of cell division) makes to cell cycle regulation are described. The part played by calcium and calcium-controlled regulatory proteins is emphasized. The importance of phosphatase as well as kinase activity to cell cycle regulation is stressed. The last words are reserved for the mitotic kinase: the last chapters describe its effects and its regulation in cell-free systems.
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CHAPTER 4 CALCIUM AND CALMODULIN REGULATION OF THE NUCLEAR DIVISION CYCLE OF ASPERGlLLUS NIDULANS
Acad acid activity of centrosomes anaphase anaphase onset antibodies arrest Aspergillus nidulans assembly asters Biochem Borisy Ca2+ calcineurin calcium calmodulin calmodulin levels CaM kinase cdc2 kinase cdc25 protein Cell Biol cell cycle cell growth Cell Sci centrioles centrosome centrosome reproduction chromatin chromosomes concentration cyclin cytokinesis cytoplasmic DNA replication EMBO embryos encoding entry into mitosis enzyme essential etal eukaryotic fission yeast function genetic induce inhibited interaction interphase intracellular Karsenti kinase activity Kirschner Lohka M-phase Maller membrane metaphase microtubule dynamics microtubule nucleation mitosis molecular MTOC mutation Natl Nigg NIMA nimA5 normal nuclear division cycle nuclear envelope nuclear envelope breakdown nuclear lamina nuclear lamins nucleating activity nuclei Nurse oocytes Osmani pathway pericentriolar material phase phenotype phosphorylation pombe ppa2 prophase protein kinase protein phosphatase regulation role Saccharomyces cerevisiae sea urchin serine/threonine Sluder specific spindle pole substrate subunit target tion tubulin tyrosine phosphorylation vitro vivo Xenopus egg extracts zygotes Сад