Cell Fusions: Regulation and Control

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Lars-Inge Larsson
Springer Science & Business Media, Nov 22, 2010 - Medical - 436 pages
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Cell fusions are important to fertilization, placentation, development of skeletal muscle and bone, calcium homeostasis and the immune defence system. Additionally, cell fusions participate in tissue repair and may be important to cancer development and progression. A large number of factors appear to regulate cell fusions, including receptors and ligands, membrane domain organizing proteins, proteases, signaling molecules and fusogenic proteins forming alpha-helical bundles that bring membranes close together. The purpose of the planned volume is to sum up current knowledge about mechanisms regulating and controlling cell fusions. The field has expanded vastly within the past few years and leaders in the field will be invited to contribute with current overviews of their specific areas of knowledge. Attention will be paid both to true fusogens like proteins encoded by the viral (e.g. HIV), caenorhabdidtis (EFF) mammalian and human (e.g. syncytins and Pb-1) genomes as well as to mechanisms regulating the activities of the fusogens. The commitment of cells to fuse represents an irreversible step. It stands to reason that a number of factors controlling and safe-guarding these mechanisms must exist. It seems equally reasonable to assume that many of these mechanisms are redundant in different systems. By bringing together experts working in each their system there is a fair chance that a consensus concerning the mechanistics of cell fusions may develop.
 

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Contents

1 Regulation and Control of CellCell Fusions
1
Overview
11
Regulation by Proteolytic Processing and Cellular Factors
41
4 A Comparative Portrait of Retroviral Fusogens and Syncytins
63
Molecular Aspects
117
6 Role of the Actin Cytoskeleton Within FuRMAS During Drosophila Myoblast Fusion and First Functionally Conserved Factors in Vertebrates
139
7 Role of CD9 in SpermEgg Fusion and Its General Role in Fusion Phenomena
171
8 Gamete Binding and Fusion
185
11 Molecules Regulating Macrophage Fusions
233
12 Current Progress Towards Understanding Mechanisms of Myoblast Fusion in Mammals
249
13 The Endogenous Envelope Protein Syncytin Is Involved in Myoblast Fusion
267
14 Cell Fusion and Stem Cells
277
15 Cell Fusion and Dendritic CellBased Vaccines
315
Implications for Energy Metabolism in Malignant Hybrids
351
17 CellCell Fusions and Human Endogenous Retroviruses in Cancer
395
Index
427

9 Mechanisms Regulating Human Trophoblast Fusion
203
The Making of a New Cell
219

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