Cell Migration: Signalling and Mechanisms

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Frank Entschladen, Kurt S. Zšnker
Karger Medical and Scientific Publishers, 2010 - Science - 176 pages
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Cell migration is a highly complex process which involves several compartments of the cell, including surface receptors, signalling elements and the cytoskeleton. It plays an essential role in embryogenesis, wound healing and inflammatory responses, and a dysregulation of cell movement can cause pathological states such as developmental defects, chronic inflammation, cancer invasion and metastasis. Covering extracellular regulatory signals and intracellular signal transduction pathways as well as the molecular mechanisms of migration in stem cells, leukocytes and tumor cells in the adult human organism, this book summarizes the current state of knowledge about cell migration. In the first part, the major aspects of different migratory cells in health and disease are covered, with special emphasis on T lymphocytes. The second part provides a comprehensive overview of the principal molecular mechanisms of migration such as adhesion receptors, cytoskeletal rearrangements and locomotor force generation, which, together, can be referred to as a cell's 'migrosome'.With contributions by eminent international scientists from different disciplines this book will serve as a valuable resource not only for researchers in cell biology, immunology and oncology, but also for clinicians who wish to learn more about the role of migratory processes in health and disease.
 

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Contents

Stem Cell Migration in Health and Disease
7
Leukocyte Motility and Human Disease
28
Coordination of Leukocyte Polarity and Migration
40
Positioning Phosphoinositide 3Kinase in Chemokine and AntigenDependent
54
TFH Cells Th17 Cells
67
ADAMs and Ectodomain Proteolytic Shedding in Leukocyte and Tumour Cell
83
Signals and Pathways
102
Regulation of the ECadherin Adhesion Complex in Tumor Cell Migration and Invasion
120
Understanding Adaptor Proteins
136
Locomotor Force Generation by Myosins
163
Author Index
173
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