Elsevier, Aug 25, 1998 - Science - 258 pages
Few cells conform to the stereotype of the spherical blob hastily scribbled on chalkboards and, regrettably, sometimes even displayed prominently in textbooks. Instead, real cells display a remarkable degree of structural and functional asymmetry. In modern cell biological parlance, this asymmetry has come to be lumped under the general heading of "cell polarity". Cell polarity is by no means restricted to the cells of tissues and organs, but can also be displayed by cells that lead a more solitary existence. The amazing extent to which cell morphology is correlated with function has long been a source of inspiration for biologists. Today the fascination continues unabated in the field of cell polarity, where it is fueled by an ever-deepening appreciation for the ways that fundamental cellular processes, such as membrane trafficking and cytoskeleton assembly, contribute to the establishment and maintenance of cell polarity. In the ensuing chapters, a collection of experts will summarize and interpret the findings obtained from basic research on cell polarity in a diverse array of experimental systems.
What people are saying - Write a review
We haven't found any reviews in the usual places.
CHAPTER 3 SIGNALS AND MECHANISMS OF SORTING IN EPITHELIAL POLARITY
Other editions - View all
Acad actin activity adhesion alignment apical assembly axonal basolateral Biochem blastocyst blastomeres caveolae Cell Biol cell cycle cell polarity cell surface cell types complex components costamere culture cytokinesis cytoplasmic cytoskeletal defects depolarization DHPR differentiation distribution domains Drubin dystrophin ﬁbers ﬁbroblasts Figure ﬁlament ﬁrst Fleming Franzini-Armstrong function gene genetic glycoprotein Golgi GTP-binding protein GTPase identiﬁed inhibition integrin interactions intracellular kinase leading lamellae localization mating MDCK cells mechanism membrane proteins microtubules molecular molecules morphogenesis mouse embryo mRNA mutants Myo2p myoﬁbrils Natl neurons Novick ofthe pathway pheromone plasma membrane polarized cell polarized epithelial cells polarized growth preimplantation Pringle Proc projection formation receptor regulated Review Rholp Rodriguez-Boulan role ryanodine receptor Saccharomyces cerevisiae sarcolemma secretory sequence skeletal muscle Snyder sorting signal Spa2p speciﬁc structure studies subunit surface SL T-tubular T-tubules targeting tight junction tion tissue transmembrane transport trophectoderm type A margins vesicles vinculin vitro yeast