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Biological problems in the measurement of survival at low doses
analysis in terms of
The estimation of survival at low doses and the limits of resolution
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absorbed dose aerobic Alper ampoules anoxic argon Barendsen Biol biological cell cycle cell line cell survival curve cells irradiated cellular Chinese hamster Chinese hamster cells concentration culture cyclic AMP decrease Denekamp diamide dose fractions dose per fraction double-strand breaks effect Elkind EMT6 equation experimental experiments exponential extrapolation number factors fitted gamma rays high doses high-LET hypoxia hypoxic cells inactivation increase initial slope interval ionizing ionizing radiation krad Leenhouts lethal low dose rate mammalian cells mice mutation neutrons nitrogen number of fractions observed obtained one-hit oxygen oxygen enhancement ratio parameters phase plating efficiency points population rad min"1 radiation radiation reaction Radiobiology radiosensitivity recovery region repair of sublethal replication Revesz sampling sensitive shape shoulder shown in figure shows single doses slope ratio spheroids split-dose sublethal damage survival-curve surviving fraction synchronized tion tissue TMPN total dose tumour V79 cells values variation vitro vivo x-rays