Oxford University Press, Aug 5, 2004 - Science - 240 pages
The completion of the first draft of the human genome has led to an explosion of interest in genetics and molecular biology. The view of the genome as a network of interacting computational components is well-established, but researchers are now trying to reverse the analogy, by using living organisms to construct logic circuits. The potential applications for such technologies is huge, ranging from bio-sensors, through industrial applications to drug delivery and diagnostics. This book would be the first to deal with the implementation of this technology, describing several working experimental demonstrations using cells as components of logic circuits, building toward computers incorporating biological components in their functioning.
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actin I gene activity aligned bacteria behavior binding biochemical biocircuit design biofilms biological bioluminescence bioreporter BioSPICE Biotechnol carbon nanofiber cellular computing chemical chromosome ciliates communication complex components concentration conjugative plasmid described device physics dimers DNA molecules encoding enzyme enzyme GP enzyme’s Escherichia coli evolution excision faecalis Figure fluorescence gene expression genetic circuits genetic programming genome IESs implement inducer information processing input mRNA input protein input signal interactions interface intracellular inverter IPTG logic circuits logic gates LuxI LuxR MDSs metabolic Microbiol micronuclear micronuclear DNA micronuclear gene microscale molecular mRNA mutation nanofiber nanoscale networks OG1SSp operator operon output pairs parse tree pathways pheromone plasmid pointers production promoter quorum sensing reactions recombination regulatory reporter gene repressor response scrambled sender cells sequences simulation solutions specific Sterkiella nova stichotrich structure Stylonychia substrate transcription transfer curve transfer function VACNF Vibrio fischeri whole-cell
Page 10 - In John R. Koza, Wolfgang Banzhaf, Kumar Chellapilla, Kalyanmoy Deb, Marco Dorigo, David B. Fogel, Max H. Garzon, David E. Goldberg, Hitoshi Iba, and Rick Riolo, editors, Genetic Programming 1998: Proceedings of the Third Annual Conference, pages 152-157, University of Wisconsin, Madison, Wisconsin, USA, 22-25 July 1998.
Page 13 - ... one cell may respond by increasing its DNA content to reach the standard amount. The other cell may discard the excess DNA. There must be numerous homeostatic adjustments required of cells. The sensing devices and the signals that initiate these adjustments are beyond our present ability to fathom. A goal for the future would be to determine the extent of knowledge the cell has of itself, and how it utilizes this knowledge in a "thoughtful