Cellular and Molecular Biology of Myelination
Gunnar Jeserich, Hans H. Althaus, Thomas V. Waehneldt
Springer, Jan 1, 1990 - Myelination - 565 pages
Experts in the field of cellular and molecular biology of myelination present their latest results. Various techniques were used such as tissue culture, transplantation, transfection, immunocytochemistry and approaches to study the phylogenetic aspects of myelination as well as molec- ular biology. Concerning glial cells: hormones and second messengers play an important role in the regulation of the phenotype and the expression of myelin components at the transcriptional level; these findings are also part of particular relevance for remyelination. Concerning myelin: compositional studies revealed an increasing number of minor components to be of crucial importance for cellular adhesion processes; from a phylogenetic point of view vertebrate myelin has existed for 400 million years with important alterations in its compositon. This book offers a superb collection of the latest results presented by internationally reknowned scientists.
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MOLECULAR APPROACHES TO THE STUDY OF THE REGULATION
FROM MYELIN BASIC PROTEIN TO MYELIN DEFICIENT MICE
FROM THE PRIMARY STRUCTURE
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Acad Sci USA activity adult antigen astrocytes axons binding biochemical bovine Brain Res cDNA Cell Biol cell cultures central nervous system cloning CNS myelin components cytoplasmic demyelination developmental differentiation Dubois-Dalcq exon extracellular fetal Figure galactocerebroside gene expression GFAP glial cells glycoprotein growth factor immunocytochemical immunoreactivity immunostaining isolated Jeserich lesion lipid macrophages mammalian markers Matthieu MBP gene McMorris mice mitogenic molecules morphology mouse mRNA mutant myelin basic protein myelin membrane myelin proteins myelin sheath myelin-associated myelin-associated glycoprotein Natl Acad Sci Neurochem neurons Neurosci normal oligodendrocytes oligodendroglial optic nerve PDGF peripheral PLP gene Poduslo polypeptide present Proc Natl Acad processes proliferation protein kinase proteolipid protein rat brain rat optic nerve receptors regulation Schwann cells sciatic nerve sequence shiverer sodium channels specific spinal cord squalene staining structure studies subunit synthesis Szuchet tellurium tissue transcription transfected vitro vivo Waehneldt