Cerebral Blood Flow: Mechanisms of Ischemia, Diagnosis and Therapy

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M.R. Pinsky
Springer Science & Business Media, 2002 - Medical - 308 pages
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This volume covers the most important aspects of cerebral blood flow (CBF) from bench to bedside. It first defines the basic physiology of CBF, those qualities that make it unique or are shared with other organs and their clinical implications. There follows a section on CBF pathophysiology that explores many of the known and proposed mechanisms of cerebral ischemia in stroke and trauma states. The third section describes the numerous and powerful means available to measure blood flow, tissue function and overall perfusion. These are essential measures if one is to assess the effectiveness of therapies aimed at preventing or reversing cerebral ischemia. The final section describes the interesting and often successful recent clinical trials aimed at preventing or reversing cerebral ischemia. This collection of multicenter trial data and their implications in one volume is unique in this field. This book addresses all the major aspects of CBF from basic issues to clinical practice.
 

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Contents

History of Cerebral Blood Flow Assessment
3
Neural Regulation of the Cerebral Circulation
7
Role of Endothelium in Regulation of the Brain Microcirculation
17
Current Concepts and Future Directions
26
Ischemic Brain Injury
43
Triggering Events in Ischemic Brain Damage
45
Ischemic Mechanisms in Traumatic Brain Injury
60
Coupling and Compartmentation
72
Computed Tomography Angiography and Perfusion Imaging of Acute Stroke
165
The Use of XenonCT Cerebral Blood Flow Studies in Acute Stroke
179
Advances in Imaging in Ischemic Stroke
191
Assessment of Cerebrovascular Pathophysiology
201
Cerebral Blood Flow Measurement with Positron Emission Tomography
217
Current Status of Clinical Trials in Acute Stroke
227
Thrombolysis for Acute Stroke
229
A Ten Year Dry Season
236

The Genetic Control of Ischemic Neuronal Cell Death
96
Cerebral Resuscitation from Temporary Complete Global Brain Ischemia
106
Pathophysiology and Therapeutic Implications
137
Assessment of Cerebral Blood Flow
147
The Assessment of Determinants of Cerebral Oxygenation and Microcirculation
149
Extracranial and Intracranial Angioplasty and Stenting
252
Therapeutic Moderate Hypothermia and Fever
272
Is There a Role for Cerebral Revascularization?
277
Subject Index
299
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About the author (2002)

Michael R. Pinsky, MD is a professor of Critical Care medicine, Bioengineering and Anaesthesiology at the University of Pittsburgh and Dr hc from the University of Paris (La Sorbonne). He is considered an expert in hemodynamic monitoring, cardiovascular and pulmonary physiology and the treatments of cardio-respiratory diseases, including septic shock, ARDS and transplantation.

Didier Payen, MD is a professor and chairman of Anaesthesiology and Critical Care Medicine at Laribosiere Hospital, Paris and the president of the European Society of Intensive care Medicine. He is considered an expert in hemodynamic monitoring, organ transplantation, nitric oxide metabolism and treatment and cardiovascular physiology.

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