Cerebral Cortex: Neurodegenerative and Age-Related Changes in Structure and Function of Cerebral Cortex
Alan Peters, John H. Morrison
Springer Science & Business Media, Sep 30, 1999 - Medical - 783 pages
This volume of Cerebral Cortex is dedicated to Sir John Eccles, who was an active member of the advisory board for the series until his death in May 1997. His input as to what topics should be covered in future volumes of this series will be sorely missed. The present volume is concerned with neurodegenerative disorders and age related changes in the structure and function of the cerebral cortex, a topic that has attracted increasing interest as longevity and the number of aged individuals in the population increase. Although much of the research on the neurodegenerative effects of aging has been centered on Alzheimer's disease, most of the aging popu lation will not be afflicted by this disease. They will, however, be affected by the consequences of normal aging, so the first few chapters of this volume are con cerned with that topic. Chapter 1, by Marilyn S. Albert and Mark B. Moss, gives an account of the cognitive changes that accompany normal human aging. Chapter 2, by Mark B.
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Acad Acta Neuropathol adult aged monkeys allele alterations Alzheimer Alzheimer's disease amygdala amyloid deposits antibody areas Arnsten associated astrocytes atrophy axons basal forebrain binding Bouras Braak Brain Res cell loss cerebral cortex CHAPTER cholinergic cingulate clinical cognitive Comp correlation cortical decrease deficits degeneration dementing dendritic disorders distribution effects entorhinal cortex filaments function gene genetic glial glutamate receptor hippocampal formation Hirano Hyman immunoreactivity impairment laminar layer lesions Lewy body Masliah medial memory molecular Morrison motor mRNA Natl neocortex neocortical nerve growth factor Neurobiol neurochemical neurodegeneration neurofibrillary tangles neurofilament Neurology neuronal loss neuropil neuropil threads Neurosci neurotrophic factor NMDA normal aging nucleus basalis observed parietal pathology patients pattern phosphorylated Pick's disease prefrontal cortex primate progressive supranuclear palsy projections Psychiatry pyramidal neurons regions rhesus monkey senile plaques studies subcortical subtypes subunits suggest synaptic syndrome tau protein temporal lobe tion trophic factors visual vulnerable