Cerebral Plasticity: New Perspectives

Front Cover
Leo M. Chalupa, Nicoletta Berardi, Matteo Caleo, Lucia Galli-Resta, Tommaso Pizzorusso
MIT Press, May 20, 2011 - Medical - 432 pages

A survey of the latest research, covering such topics as plasticity in the adult brain and the underlying mechanisms of plasticity.

The notion that neurons in the living brain can change in response to experience—a phenomenon known as "plasticity"—has become a major conceptual issue in neuroscience research as well as a practical focus for the fields of neural rehabilitation and neurodegenerative disease. Early work dealt with the plasticity of the developing brain and demonstrated the critical role played by sensory experience in normal development. Two broader themes have emerged in recent studies: the plasticity of the adult brain (one of the most rapidly developing areas of current research) and the search for the underlying mechanisms of plasticity—explanations for the cellular, molecular, and epigenetic factors controlling plasticity. Many scientists believe that achieving a fundamental understanding of what underlies neuronal plasticity could help us treat neurological disorders and even improve the learning capabilities of the human brain.

This volume offers contributions from leaders in the field that cover all three approaches to the study of cerebral plasticity. Chapters treat normal development and the influences of environmental manipulations; cerebral plasticity in adulthood; and underlying mechanisms of plasticity. Other chapters deal with plastic changes in neurological conditions and with the enhancement of plasticity as a strategy for brain repair.

 

What people are saying - Write a review

We haven't found any reviews in the usual places.

Contents

1 Introduction
1
2 The Dynamic Building of the Brain
5
3 The Plasticity of Retinal Ganglion Cells
25
4 Using Indelible Transgenic Markers to Identify Analyze and Manipulate Neuronal Subtypes
35
5 VisionDependent Plasticity at the Retinogeniculate Synapse
49
6 Is Half a Loaf Worse than No Bread?
63
7 Determinants of Synaptic and Circuit Plasticity in the Cerebral Cortex
75
8 ActivityDependent Development of Inhibitory Synapses and Innervation Pattern in the Visual Cortex
89
18 Modulation of Synaptic NMDA Receptors in Striatal Medium Spiny Neurons by Endogenous Dopamine
227
19 What Is Callosal Plasticity?
235
20 Time Matters
247
21 The Two Dorsal Visual Streams and Their Role in Perception
259
22 The Tribal Networks of the Cerebral Cortex
275
23 Neurophysiological Correlates of Cortical Plasticity in the Normal and Diseased Human Brain
291
24 Subcortical Contributions to Cortical Reorganization after Massive Somatosensory Deafferentation
303
25 Environmental Influences on Neurodegenerative Disease
315

9 Molecular Factors Controlling Inhibitory Circuit Maturation and Onset of Critical Period Plasticity
101
10 NeuronAstrocyte Partnership in Brain Function and Dysfunction
113
11 A Thorny Question
127
12 The Glutamate Receptor delta2 Subunit in Cerebellar Wiring
139
13 Cortex under Construction
151
14 Neural Plasticity in Humans
165
15 The Developmental Process of Acquiring Multisensory Integration Capabilities
179
16 Auditory Processing and Plasticity
201
17 Functional Plasticity of the Auditory Cortex
215
26 Nerve Growth Factor and Alzheimers Disease
325
27 Neurotrophins as Regulators of Visual Cortical Plasticity
343
28 Plasticity in the Developing Brain
355
29 Suppression of NogoA to Enhance CNS Repair
367
30 New Perspectives in the Treatment of Amblyopia
383
Contributors
395
Index
399
Insert
417
Copyright

Other editions - View all

Common terms and phrases

About the author (2011)

Leo M. Chalupa is Vice President for Research and Professor of Pharmacology and Physiology at George Washington University.

Barbara Chapman is Professor of Computer Science at the University of Houston.

Barry E. Stein is Professor and Chair of the Department of Neurobiology and Anatomy at Wake Forest University School of Medicine. His previous books on this topic include The Merging of the Senses (MIT Press, 1993) and The Handbook of Multisensory Processes (MIT Press, 2004).

Wolf Singer is Emeritus Director of the Max Planck Institute for Brain Research and Founding Director of the Frankfurt Institute for Advanced Studies and the Ernst Strüngmann Institute for Neuroscience in cooperation with the Max Planck Society, where he is also Senior Research Fellow. He is the coauthor of Beyond the Self: Conversations between Buddhism and Neuroscience (MIT Press).

Giacomo Rizzolatti is Professor of Human Physiology at the University of Parma.

Bibliographic information