Cerebral Plasticity: New Perspectives
Leo M. Chalupa, Nicoletta Berardi, Matteo Caleo, Lucia Galli-Resta, Tommaso Pizzorusso
MIT Press, May 20, 2011 - Medical - 432 pages
A survey of the latest research, covering such topics as plasticity in the adult brain and the underlying mechanisms of plasticity.
The notion that neurons in the living brain can change in response to experience—a phenomenon known as "plasticity"—has become a major conceptual issue in neuroscience research as well as a practical focus for the fields of neural rehabilitation and neurodegenerative disease. Early work dealt with the plasticity of the developing brain and demonstrated the critical role played by sensory experience in normal development. Two broader themes have emerged in recent studies: the plasticity of the adult brain (one of the most rapidly developing areas of current research) and the search for the underlying mechanisms of plasticity—explanations for the cellular, molecular, and epigenetic factors controlling plasticity. Many scientists believe that achieving a fundamental understanding of what underlies neuronal plasticity could help us treat neurological disorders and even improve the learning capabilities of the human brain.
This volume offers contributions from leaders in the field that cover all three approaches to the study of cerebral plasticity. Chapters treat normal development and the influences of environmental manipulations; cerebral plasticity in adulthood; and underlying mechanisms of plasticity. Other chapters deal with plastic changes in neurological conditions and with the enhancement of plasticity as a strategy for brain repair.
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3 The Plasticity of Retinal Ganglion Cells
4 Using Indelible Transgenic Markers to Identify Analyze and Manipulate Neuronal Subtypes
5 VisionDependent Plasticity at the Retinogeniculate Synapse
6 Is Half a Loaf Worse than No Bread?
7 Determinants of Synaptic and Circuit Plasticity in the Cerebral Cortex
8 ActivityDependent Development of Inhibitory Synapses and Innervation Pattern in the Visual Cortex
18 Modulation of Synaptic NMDA Receptors in Striatal Medium Spiny Neurons by Endogenous Dopamine
19 What Is Callosal Plasticity?
20 Time Matters
21 The Two Dorsal Visual Streams and Their Role in Perception
22 The Tribal Networks of the Cerebral Cortex
23 Neurophysiological Correlates of Cortical Plasticity in the Normal and Diseased Human Brain
24 Subcortical Contributions to Cortical Reorganization after Massive Somatosensory Deafferentation
25 Environmental Influences on Neurodegenerative Disease
9 Molecular Factors Controlling Inhibitory Circuit Maturation and Onset of Critical Period Plasticity
10 NeuronAstrocyte Partnership in Brain Function and Dysfunction
11 A Thorny Question
12 The Glutamate Receptor delta2 Subunit in Cerebellar Wiring
13 Cortex under Construction
14 Neural Plasticity in Humans
15 The Developmental Process of Acquiring Multisensory Integration Capabilities
16 Auditory Processing and Plasticity
17 Functional Plasticity of the Auditory Cortex
26 Nerve Growth Factor and Alzheimers Disease
27 Neurotrophins as Regulators of Visual Cortical Plasticity
28 Plasticity in the Developing Brain
29 Suppression of NogoA to Enhance CNS Repair
30 New Perspectives in the Treatment of Amblyopia