Cerebral Vasospasm: Advances in Research and Treatment

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Thieme, Jan 1, 2011 - Medical - 333 pages
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With contributions from the top neurovascular centers around the world, this valuable resource explores the remarkable progress made in treating cerebral vasospasm, enhanced by nearly 200 high-quality illustrations. Coverage includes: the role of potassium channels, the use of PET scanning, management with thrombolytic agents, decision analysis in treatment plans, and much more. You will also find the latest information on molecular mechanisms, remodeling and inflammation, experimental endothelium research, and the pathophysiology of vasospasm.Special features:Contributions from top international specialistsReviews all new clinical and research advancesOffers authoritative coverage of pathophysiology, experimental treatments, endovascular surgery, and other important management issuesNearly 200 clear images bring material to life and highlight key conceptsStraightforward text designed for easy readability and quick referenceThe study of cerebral vasospasm following aneurysmal subarachnoid hemorrhage has seen great strides in the past decade, leading to significant progress in diagnostic and therapeutic techniques. Offering an incisive summary of these advances, here is the book that all neurosurgeons, vascular specialists, emergency room physicians, and neuroradiologists need for a deeper understanding of this multi-faceted condition.
 

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Contents

Signaling Pathways in Cerebral Vasospasm
3
Changes in Vascular Ion Channels After Experimental Subarachnoid Hemorrhage
12
Potassium Channels in Experimental Cerebral Vasospasm
20
Potential Role of Potassium Channels in Tyrosine Kinase InhibitorInduced
29
Protein Kinase C Isoforms Rho Kinase and Myosin Light Chain Phosphorylation
36
Is It That Simple?
43
Activation of Microglia After Experimental Subarachnoid Hemorrhage in Rats
57
New Perspectives
65
Comparison of Positron Emission Tomography Cerebral Perfusion with Transcranial
174
Correlation Between TCD and
180
Sex and Clinical Cerebral Vasospasm in Yorkshire UK
189
Grading Scale for Subarachnoid Hemorrhage Based on a Modification of
197
The Role of Isoprostane in Vasospasm After Aneurysmal Subarachnoid Hemorrhage
204
The APACHE Score for Early Detection of Cerebral Vasospasm
212
Sequential Changes in Oxyhemoglobin in Fluid Drained from SAH Patients
216
Clinical Trial Dilemmas in Vasospasm
227

New Hypothesis
71
Experimental SAH Alters Endothelin Receptor Phenotype in Rat Cerebral Arteries
79
Increased Contractile Effect of Endothelin1 on Isolated Rat Basilar Artery after
86
Monitoring Activation of the Cerebral Endothelin System After Subarachnoid
93
A Review
103
Intravascular Adenoviral Gene Transfection of Monkey Cerebral Arteries
112
Cytosolic Calcium Oscillations Induced by Cisternal Cerebrospinal
119
Experimental SAH Upregulates 5HT1B Receptors in Rat Cerebral Arteries
126
Expression of Hypoxia Inducible Factor1 in a Rat Subarachnoid Hemorrhage Model
134
Possible Role of Heme Oxygenase1 and Ferritin in Cerebral Vasospasm After Aneurysmal
142
Prevention of Experimental Cerebral Vasospasm by Intrathecal Delivery
153
Phosphodiesterase III Inhibitor for the Treatment of Chronic Cerebral
160
Intraoperative Microvascular Doppler Sonography for Monitoring Vasospasm
167
Cerebrovascular Effects of Hypertonic Saline in Poor Grade Patients with
234
Effect of Hydrocortisone on Excess Natriuresis in Patients with Aneurysmal
240
Symptomatic Vasospasm After Early Surgical and Endovascular Treatment of Ruptured
249
CSF Drainage for Prevention and Reversal of Cerebral Vasospasm After
255
Fenestration of the Lamina Terminalis Reduces Vasospasm After Subarachnoid
263
Clinical Trial of Nicardipine ProlongedRelease Implants for Prevention of Vasospasm
269
A Pilot Study
274
Effects of Fasudil Hydrochloride a Protein Kinase Inhibitor on Cerebral Vasospasm
284
Analysis of Patients with Cerebral Infarction Caused by Vasospasm after IntraArterial
292
Effects of Intrathecal Fibrinolytic Therapy on Clot Lysis and Development
300
Prevention of Vasospasm by Cisternal Irrigation with Urokinase and Ascorbic Acid
308
Prevention of Symptomatic Vasospasm by Intermittent Cisternal Irrigation with
317
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About the author (2011)

Head, Division of Neurosurgery, St. Michaels Hospital; Professor of Surgery, University of Toronto, Toronto, Ontario, CanadaCo-Founder and Chief Scientific Officer, Edge Therapeutics Inc.

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