Cerebral Ischemia and Calcium
Alexander Hartmann, Wolfgang Kuschinsky
Springer Berlin Heidelberg, Nov 14, 1989 - Medical - 586 pages
Although many books deal with isolated problems of calcium disturbance in relation to cardiac and cerebral function, this is the first to focus specifically on calcium metabolism and cerebral ischemia. Internationally acknowledged experts present recent data and new concepts in an interdisciplinary approach to the subject. They examine basic information on the pathophysiology of cellular events, the damage caused by excitotoxic substances, and the effects of calcium antagonistic drugs as measured in experimental animals. These contributions may help lead to possible therapeutic interference for the prevention of calcium imbalance.
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acid activity acute aneurysm animals anoxia Berlin Heidelberg 1989 Blood Flow Metab blood pressure blood-brain barrier calcium antagonists calcium channel calcium channel blockers calcium entry blockers cardiac carotid cell Cereb Blood Flow cerebral blood cerebral ischemia cerebrovascular changes clinical concentration cortex cortical cytosolic decrease depolarization dihydropyridine diltiazem dose drug effect of nimodipine epilepsy experimental extracellular flunarizine free calcium gerbils glucose glutamate headache hippocampus hypertensive hypoxia increase induced infarction inhibition injection intravenous isch Ischemia and Calcium Kuschinsky lesion levels MCA occlusion measured mechanism membrane metabolism mg/kg middle cerebral artery migraine mitochondria mmHg Neurochem neurological neuronal nicardipine nifedipine nimo nimodipine NMDA normal patients perfusion Pharmacol Physiol placebo plasma platelet postischemic protein rat brain receptor reduced regions reperfusion seizures side-effects Siesjö BK smooth muscle Springer-Verlag Berlin Heidelberg Stroke subarachnoid subarachnoid hemorrhage synaptosomes tissue treatment trial vascular vasospasm verapamil vessels