Chemical Synthesis of Nucleoside Analogues
John Wiley & Sons, Feb 12, 2013 - Science - 912 pages
Compiles current tested and proven approaches to synthesize novel nucleoside analogues
Featuring contributions from leading synthetic chemists from around the world, this book brings together and describes tested and proven approaches for the chemical synthesis of common families of nucleoside analogues. Readers will learn to create new nucleoside analogues with desired therapeutic properties by using a variety of methods to chemically modify natural nucleosides, including:
Chemical Synthesis of Nucleoside Analogues covers all the major classes of nucleosides, including pronucleotides, C-nucleosides, carbanucleosides, and PNA monomers which have shown great promise as starting points for the synthesis of nucleoside analogues. The book also includes experimental procedures for key reactions related to the synthesis of nucleoside analogues, providing a valuable tool for the preparation of a number of different compounds.
Throughout the book, chemical schemes and figures help readers better understand the chemical structures of nucleoside analogues and the methods used to synthesize them. Extensive references serve as a gateway to the growing body of original research studies and reviews in the field.
Synthetically modified nucleosides have proven their value as therapeutic drugs, in particular as antiviral and antitumor agents. However, many of these nucleoside analogues have undesirable side effects. With Chemical Synthesis of Nucleoside Analogues as their guide, researchers have a new tool for synthesizing a new generation of nucleoside analogues that can be used as therapeutic drugs with fewer unwanted side effects.
What people are saying - Write a review
Chemical Synthesis of AcycIic Nucleosides
Phosphonated Nucleoside Analogues
Chemical Syntheses of Nucleoside
Mononucleotide Prodrug Synthetic Strategies
Methodologies for the Synthesis of Isomeric
Synthesis of 3SpiroSubstituted Nucleosides
Recent Advances in the Chemical Synthesis
Stereoselective Methods in the Synthesis
Synthesis of CNucleosides
Synthetic Studies on Antifungal Peptidyl
Chemical Synthesis of Conformationally
Nucleosides Modified at the Base Moiety
Recent Advances in Synthesis and Biological