Chemical mutagens: principles and methods for their detection
Analysis of body fluids including alkylation of macromolecules for detection of mutagenic agents; Use of yeast as an assay system for industrial mutagens; Heritable-translocation test in mice; Detection of mutation damage in ferm populations: an in situ bioassay for mutagens in aquatic ecosystems; The discovery of human teratogens, carcinogens, and mutagens: lessons for the future; Analysis of chromosome aberrations in mammalian germ cells; The mammalian spot test: a sensitive in vivio method for the detection of genetic alterations in somatic cells of mice; Dosimetry of chemical mutagens in eukaryote germ cells; Chick embryos for detecting environmental mutagens; Specific-locus mutations in mice; The induction of sperm-shape abnormalities in mice and humans.
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Use of Multiple Indicators on Urine Blood or Tissue
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action Administrator alkylating agents analysis animals assay BrdU Cancer carcinogens cerevisiae chemical mutagens chemical substance chick embryo chromatid chromosome aberrations color spots compounds cytogenetic cytological Detection determined distribution in commerce dominant lethals dominant-lethal mutations dose Drosophila embryo environment Environmental ethyl ethyl methanesulfonate evaluation exposure females fertility Figure forward mutation gametophytes gene conversion genetic effects genotype germ cells germ-cell stages heritable translocations heterozygotes hycanthone induced injection litter loci locus Loprieno male mice mammalian manufacture or process mated meiotic metabolic metaphase methanesulfonate method mg/kg microsomal mitomycin mitotic mouse mutagenesis mutagenic mutagenic activity mutation frequency observed oocytes paragraph partially sterile males person pigment pombe progeny radiation rule samples scored screening semen sensitive specific-locus mutations sperm abnormalities spermatocytes spermatogonia spontaneous spore sporophyte strain studies styrene subparagraph subsection substance or mixture Table technique tion translocation heterozygotes translocations treated treatment trichloroethylene urine vinyl chloride yeast