Chemistry, Health and Environment
Today's chemists need to know how hazardous the chemicals they work with are, and they want to understand the relationship between chemical and structural properties and toxicity. At the same time, modern society requires that chemists have this kowledge, as legislation makes the producers/users of chemicals responsible for any adverse effects. The book deals with the effects on both man and ecosystems. It stresses especially on the relationship between chemical structure and chemical properties/toxic effects and metabolic conversions.
This is not just another book on toxicology. What makes this book special is that it is written from a chemical point of view. This textbook applies the basic principles of reactivity and reaction possibilities of organic compounds to metabolic reactions and living systems.
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Chemicals and society
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absorbed acetic active addition alcohol aldehyde amines amino acids amounts approximately aromatic atmosphere atoms benzene blood cancer carbon dioxide carbon-carbon carboxylic acid carcinogenic caused chlorine chromosome coenzyme concentration conjugated containing conversions covalent bond cyanide cytochrome P-450 degradation diffuse dipole discussed in Chapter dose double bond efficient electron pair electronegative electrophile energy enzymatic enzymes epoxide esters example excreted exogenous chemicals exogenous compounds exposure formed function gene genotoxic glutathione halogenated hazardous heteroatom hydrocarbons hydrogen cyanide hydrolysis hydrolyzed hydroxyl immune system important intestines ketones kidneys leaving group lipophilic liver lungs mechanism membrane mercury metabolism metabolites metals methanol methyl microorganisms molecular oxygen molecules mutations nitrogen normally nucleophile orbitals organic compounds oxidation ozone peroxide phenol polar proteins radiation radical react reaction reactive reduced result shown in Figure skin solvent species structures substrate sulphate sulphur take place TCDD teratogenic tion tissues toxic toxic effects transport tumours unsaturated volatile