Chemopotentiation by Hyperthermia
M. Urano, E. Douple
VSP, 1994 - Science - 356 pages
The number of studies on the use of hyperthermia in combination with chemotherapeutic agents is steadily increasing. However, thermochemotherapy has not yet captured significant clinical interest. Therefore, this fourth volume in the book series Hyperthermia and Oncology deals with this topic, as the editors feel there is a significant potential for this combined modality as an adjuvant to palliative or definitive radiotherapy, or the use of chemotherapy alone to treat localized or advanced diseases. The articles in this volume deal with various aspects of chemotherapy combined with hyperthermia and will be of value and interest to researchers in this field.
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MECHANISMS OF THERMAL ENHANCEMENT
OF CHEMOTHERAPEUTIC AGENTS
ANTITUMCR CHEMOTHERAPY WITH HYPERTHERMIA
EXPERIMENTS TO POTENTIAL CLINICAL APPLICATION
CONTRIBUTIONS FROM CANINE STUDIES
activation energy adriamycin alkylating agents antitumor assay BCNU Biol Bleehen bleomycin Cancer Cancer Inst Cancer Res CCNU CDDP cell lines cell survival cellular chemosensitization chemotherapeutic agents chemotherapy Chinese hamster cisDDP cisplatin clinical concentration cyclophosphamide cytotoxicity damage decrease dim cells dogs effect of hyperthermia elevated temperatures etanidazole etoposide fibrosarcoma fraction FSall tumors FSallC cells glucose Hahn heat dose heat treatment Herman Honess human tumor hydralazine hyperthermia hyperthermia 43°C hypoxic cells increase inhibition injection interaction intracellular mammary carcinoma mechanism Mella melphalan metabolism mgkg mgkgT mice MISO misonidazole mitomycin mouse murine Natl nitroimidazole nitrosourea normal tissues observed Oncol Oncology Overgaard oxygen patients perfusion pharmacokinetics Phys protein radiosensitization reduced sensitivity studies survival curve Teicher therapeutic therapy thermal enhancement thermia thermochemotherapy thermotolerance toxicity treated trimodality tumor blood flow tumor growth delay uptake Urano Vaupel vitro vivo whole body hyperthermia