Chirality in Industry II: Developments in the Commercial Manufacture and Applications of Optically Active Compounds

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A. N. Collins, Gary Sheldrake, J. Crosby
John Wiley & Sons, Feb 4, 1998 - Science - 418 pages

This second volume of Chirality in Industry contains new case histories from a wide range of contributors from industry or with strong industrial connections. While it is intended that the new volume will stand on its own, Volumes I and II taken together present an up-to-date and comprehensive picture of the technologies required to produce optically active compounds on a multi-kilogramme to high tonnage scale as well as illustrating the breadth of application of these technologies; the pharmaceuticals, agrochemicals, electronics, food, flavour and fragrance industries are all represented.

Chirality in Industry II

  • All new case histories
  • Unique industrial perspective on chiral technology
  • Emphasis on scale-up and process development
  • Comparison of biocatalysis, asymmetric synthesis and classical resolution approaches

The chiral infrastructure is now largely in place and there is no reason why large-scale production should not be possible for even moderately priced single enantiomer products. The successful industrial application of chiral chemistry depends on the integration of a range of supporting technologies and there are many examples in this volume of how widely the industrial practitioner must cast the net to achieve practical production methods. As with Volume I, this new volume is of particular interest to those professionally involved in the scale-up processes for single enantiomers. However, students and researchers involved in a more academic pursuit of optical activity will also benefit from some of the facets of large-scale thinking. An economic solution is still most likely to be a simple, elegant solution.

 

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Contents

Production Methods for Chiral Nonsteroidal Antiinflammatory
19
Synthesis of Enantiomerically Pure Nucleosides
41
Rational Design in Resolutions
81
Membrane Separations in the Production
157
Four Case Studies in the Development of Biotransformation
183
Developments in
207
Development of a Fullscale Process for a Chiral Pyrrolidine
225
Development of a Multistage Chemical
245
Synthesis and Applications of Chiral Liquid Crystals
263
Biotransformation in the Production of LCarnitine
287
Asymmetric Hydrocyanation of Vinylarenes
309
Enantioselective Protonation in Fragrance Synthesis
335
a Manufacturing Process Involving a Double Inversion
353
Two Case Studies
381
Index
403
Copyright

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About the author (1998)

A. N. Collins is the editor of Chirality in Industry II: Developments in the Commercial Manufacture and Applications of Optically Active Compounds, published by Wiley.

Gary Sheldrake is the editor of Chirality in Industry II: Developments in the Commercial Manufacture and Applications of Optically Active Compounds, published by Wiley.

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