Chloride Movements Across Cellular Membranes

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Elsevier, Sep 22, 2011 - Science - 392 pages
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All living cells are surrounded by a lipidic membrane that isolates them from the often harsh environment. However, to take up nutrients, to excrete waste, and to communicate among each other, Nature has invented an incredibly diverse set of transmembrane transport proteins. Specialized transporters exist to shuttle electrically charged ions, positive cations like sodium or negative anions like chloride, across the membrane. In the recent years, tremendous progress has been made in the field of chloride transport. The present book presents the state of the art of this rapidly expanding and interest-gaining field of membrane transport. It is addressed at a broad medically, physiologically, biologically, and biophysically interested readership.

* Describes the state-of-the-art in anion transport research
* Written by leaders in the field
* Presents a timely discussion of this rapidly emerging and expanding field
 

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Contents

ChlorideTransporting Proteins in Mammalian Organisms An Overview
1
Physiological Functions of the CLC Chloride Transport Proteins
9
Structure and Function of CLC Chloride Channels and Transporters
59
Pharmacology of CLC Chloride Channels and Transporters
83
The Physiology and Pharmacology of the CFTR Cl Channel
109
Gating of Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channel
145
Functional Properties of Ca2+Dependent Cl Channels and Bestrophins Do They Correlate?
181
Cell Volume Homeostasis The Role of VolumeSensitive Chloride Channels
199
GABAergic Synaptic Transmission
215
Physiology of CationChloride Cotransporters
241
Plasma Membrane ClHCO3 Exchange Proteins
279
Orchestration of Vectorial Chloride Transport by Epithelia
329
Index
369
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