Chloride Movements Across Cellular Membranes
Elsevier, Sep 22, 2011 - Science - 392 pages
All living cells are surrounded by a lipidic membrane that isolates them from the often harsh environment. However, to take up nutrients, to excrete waste, and to communicate among each other, Nature has invented an incredibly diverse set of transmembrane transport proteins. Specialized transporters exist to shuttle electrically charged ions, positive cations like sodium or negative anions like chloride, across the membrane. In the recent years, tremendous progress has been made in the field of chloride transport. The present book presents the state of the art of this rapidly expanding and interest-gaining field of membrane transport. It is addressed at a broad medically, physiologically, biologically, and biophysically interested readership.
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ABC transporter Acad Accardi acidification Alper amino acids anion exchanger apical ATP binding ATP hydrolysis Bartter syndrome basolateral bestrophins Biol blockers C‐terminal Ca2þ Ca2þ‐activated CaCCs cell volume CFTR CFTR channel CFTR ClÀ channel channel gating Chem chloride channel ClÀ/HCO3À exchange CLC proteins ClC‐ec1 cloning cotransporter cystic fibrosis cystic fibrosis transmembrane dimer endosomal epithelial cells expression fibrosis transmembrane conductance function GABA GABAA receptors GABAergic gene Genet Guggino Hartzell HCO3À human ICl,swell inhibition inhibitors interaction intercalated cells intracellular ion channels isoforms Jentsch KCC2 KCC3 KCC4 kidney Kþ channel Kþ‐ClÀ cotransport mammalian mechanism mediated mice modulation molecular mouse mutations Natl Naþ NBD1 NBD2 NBDs neurons Neurosci NKCC1 NKCC2 oocytes osteopetrosis pathway PDZ domain phosphorylation Physiol physiological plasma membrane pore postsynaptic potential protein kinase proximal tubule Pusch receptors renal residues role secretion skeletal muscle structure subunit synaptic tissues transmembrane conductance regulator tubule vesicles voltage Wang Xenopus oocytes