Springer Science & Business Media, Jan 24, 2009 - Medical - 321 pages
To start with, we feel that we should explain why the book has been entitled Cholera Toxins. In fact, the enterotoxin secreted by Vibrio cholerae, which is p- marily responsible for causation of the disease, is conventionally known as or referred to as cholera toxin, or CT. By using the word “toxins” (in its plural form), we wanted to cover all of the different types of toxins—and not just CT—produced by V. cholerae. We could have used the title Toxins of Vibrio cholerae, but we believe that Cholera Toxins is simpler and equally as expressive. However, due to its relative importance, the story of CT covers most of this book. Also, compared to all other toxins of V. cholerae, CT has been investigated more extensively. This book was jointly written by us. It is not a multiauthor book in which each expert writes one chapter. In that respect our task is harder. On the other hand, it has given us the unique opportunity to present the entire subject in the way that we conceived it. Besides, our objective is to cater to the needs of not only active research scientists but also students from different disciplines—microbiology, molecular physiology and pharmacology, basic medicines, etc. —and as such, we have attempted to present the subject in a way that will be appreciated by general readers. Further, we have provided some information that students and predoctoral researchers may find useful at the end of the book.
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actin activity adenylate cyclase adjuvant amino acid antibodies antigen bacterial Bacteriol binding biofilm Biol biosynthesis Chatterjee and Chaudhuri cholera toxin cholera toxin CT cholera vaccine cholerae cells cholerae El Tor cholerae strains chromosome classical cloned colonization complex core-PS CTA1 cytosol domain DsbA El Tor encoding endotoxins enterotoxin epidemic EpsE Escherichia coli expression extracellular function ganglioside gene cluster genetic genome Gram-negative holotoxin homologous immune response Inaba Infect Immun interaction intestinal isolated Kaper lipid lipid rafts lipopolysaccharide Mekalanos Microbiol molecular molecule mutants NAG-ST O-Ag O-antigen O-PS O139 strains Ogawa outer membrane pandemic pathogenic pathway pentamer periplasmic phage pili pilus polysaccharide present produced protein receptor region residues role rstA RTX toxin secretion sequence serogroups serotype Stroeher structure studies subunit T2SS tcpA TcpP tcpPH tion Tor strain ToxR ToxT transcription vaccine Vibrio cholerae Vibrio cholerae O1 vibriocidal virulence genes vitro Waldor