Cholesterol Regulation of Ion Channels and Receptors
Examines new research on the role of cholesterol in regulating ion channels and receptors and its effect on health
Drawing together and analyzing all the latest research findings, this book explores the role of cholesterol in the regulation of ion channels and receptors, including its pathological effects. It is the first book to comprehensively describe the complex mechanisms by which cholesterol regulates two major classes of membrane proteins. Moreover, it sheds new light on how cholesterol affects essential cellular functions such as the contraction of the heart, propagation of nerve impulses, and regulation of blood pressure and kidney function.
Written and edited by leading pioneers in the field, Cholesterol Regulation of Ion Channels and Receptors is divided into three parts:
Increased levels of cholesterol represent a major health risk. Understanding cholesterol regulation of ion channels and receptors is essential for facilitating the development of new therapeutic strategies to alleviate the impact of pathological cholesterol conditions. With this book as their guide, readers have access to the most current knowledge in the field.
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13 How Does Cholesterol Enter Mammalian Cells?
14 Vesicular Cholesterol Trafficking Along the Endocytic and Secretory Pathway
15 Nonvesicular Cholesterol Transport
16 Cholesterol Efflux from Cells
83 Concluding Remarks and Future Directions
92 The AChR is Surrounded by Lipids in the LiquidOrdered Phase
93 Stoichiometry and Selectivity of the ProteinVicinal Lipid
94 Influence of Cholesterol on AChR Secondary Structure
95 Influence of Cholesterol on AgonistInduced Conformational States and Ion Translocation Function
from Bacterial Homologs to Eukaryotes
97 Cholesterol Binding to Nonannular Sites on the AChR Molecule
23 Protein Regulation by CholesterolInduced Changes in Bilayer Physical Properties
24 CholesterolInduced Changes in Quantitative Estimates
25 Methods for Identifying Protein Regulation by Changes in Bilayer Physical Properties
26 Cholesterol Regulation of Membrane Proteins in Living Cells
27 Physiological Role of CholesterolInduced Changes in Bilayer Physical Properties
32 Cholesterol Suppresses Kir2 Activity InVitro and InVivo
33 Evidence for Specific SterolProtein Interactions in the Regulation of Kir Channels
34 Structural Determinants of Cholesterol Sensitivity of Kir2 Channels
35 Physiological Impact of CholesterolInduced Suppression of Kir2 Channels
36 Concluding Remarks and Future Directions
42 Molecular Components of SOCE
43 Lipid Raft Domains and Caveolae
44 The Role of Lipid Raft Domains in the Regulation of TRPC1
45 Molecular Complexity in the Regulation of SOCE
53 Mechanisms of Cholesterol Effects on Ion Channels
54 Cholesterol as a Target for Therapeutic Agents
61 BK Channels and Steroids
71 Potassium Channels in the Immune System
72 Regulation of Potassium Channels by Membrane Cholesterol and Lipid Raft Microdomains
73 Localization of Major VoltageDependent Kv13 and Kv15 Channels in CholesterolRich Membrane Microdomains in Leukocytes
The Immunological Synapse
Structure and Multilayered Regulation
98 A New CholesterolRecognition Motif in the AChR is also Present in GPCRs
102 Presence of CholesterolBinding Domains?
103 Presence of CholesterolRich Microdomains?
104 Alterations in Protein Function Induced by Changes in the Cholesterol Content in MembranesCells?
105 Alterations in Receptor Function Following Substitution of Cholesterol by Sterol Analogs? Correlation of Receptor Function with Membrane Par...
106 CholesterolBinding Molecules as Functional Cholesterol Competitors?
107 Cholesterol Requirement for Heterologous Over Expression Solubilization and Purification of Receptors?
108 Direct Interaction of the Receptor with Labeled Cholesterol Probes?
109 Concluding Remarks
112 GPCR Structural Biology Comes of Age
113 Cholesterol is Physiologically Important
114 Gaining Insights into CholesterolGPCR Interactions
115 Structural Characterization of CholesterolBinding Site in Adrenergic Receptors
117 Direct Effect of Cholesterol on β2AR
119 Structural Insight on Stabilizing Effect of Cholesterol
1111 CholesterolBinding Site in the Crystal Structure of β1AR
Structure and Membrane Organization
The Serotonin1A Receptor
123 Acute Versus Chronic Cholesterol Depletion
124 Cholesterol Binding Sites in GPCRs
Implications in Pathogen Entry
131 TollLike Receptor Signaling
132 Lipid Rafts and TLR Signaling