Cholinergic Mechanisms: From Molecular Biology to Clinical Significance

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J. Klein, K. Löffelholz
Elsevier, Dec 18, 1996 - Medical - 376 pages
This volume offers a comprehensive update and overview of the field of cholinergic transmission as presented by some thirty distinguished investigators who were recruited for their task from Germany, Great Britain, Canada, USA, Sweden, Israel, France and Italy. Exciting new discoveries, described in this volume, are due to recent methodological breakthroughs. These discoveries throw new light on many areas of cholinergic mechanisms.
 

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Contents

Loewis discovery and the XXI century
1
Neurobiology of Cholinergic Transmission
29
Vesicular Acetylcholine Transporter
67
Neuronal Nicotinic Receptors
105
Muscarinic Receptors 1 Structural Aspects
139
Muscarinic Receptors 2 Mechanisms of Desensitization
163
Muscarinic Receptors 3 Coupling to Intracellular Signalling Pathways
189
Presynaptic Modulation of Acetylcholine Release
217
Cholinergic Dysfunction 1 Animal Models
251
Cholinergic Dysfunction 2 Mechanisms in Dementia
283
Cholinergic Dysfunction 3 Trophic Factors
325
Subject Index
373
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