Cholinergic Ligand Interactions
D. J. Triggle, J. F. Moran, Eric A. Barnard
Academic Press, Jan 1, 1971 - Cholinergic mechanisms - 204 pages
Cholinergic Ligand Interactions presents the papers read at a symposium held at the State University of New York at Buffalo, 25-26 May 1970. The recent purification and crystallization of acetylcholinesterase together with real progress in the purification of receptor components indicated the desirability of organizing a symposium to discuss not only these aspects but also the structural bases for cholinergic ligand interaction with these macromolecules, the conformational changes involved with ligand binding, the quantitation of cholinergic ligand binding sites, and the roles of acetylcholinesterase and its isozymes in muscle disease.
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Studies on the Subunits of Acetylcholinesterase
In Vitro Studies with the Cholinergic Receptor of
Binding of Cholinergic Ligands to Electroplaxes
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AcChE acetylcholine acetylcholinesterase AChE activity acid acrylamide acrylamide gels affinity agonist allosteric anionic antagonist antiperiplanar assay atropine bands BChE Belleau biceps muscle binding sites Biochem Biol bond carbamylcholine catalytic cell Changeux Chem chick chicken choline cholinergic ligands cholinergic receptor cholinesterases Chothia and Pauling compounds concentration d-tubocurarine D. J. Triggle decamethonium decarbamylation denervated DFP-reactive sites diaphragm drugs dystrophic muscle E. A. Barnard edrophonium Ehrenpreis electronic electroplax embryo embryo muscle endplate enzyme equilibrium dialysis esterase esters fibers Figure forms function H. G. Mautner Histochem hydrolysis inhibition inhibitor innervated interaction iodide isozymes labeled latissimus dorsi Leuzinger ligand membrane methyl molecular weight molecules Moran motor end plates muscular dystrophy myotubes Nachmansohn nerve nicotinic non-specific nonpolar normal pectoral muscle Pharmacol pharmacological Podleski Proc protein pseudo-ChE quaternary reaction response Shefter species steric structure studies substrate subunits surface synaptic synclinal synclinal conformation Table tissue Torpedo plax values vitro vivo Wilson