Chromatin Structure and Gene Expression
Sarah C. R. Elgin
IRL Press, 1995 - Chromatin - 224 pages
Due to advances in molecular biology techniques, chromatin structure and function has re-emerged as a key research area in the investigation of gene regulation and expression. This indispensable new book provides the busy researcher with an overview of all the latest research in this important area. Topicality and breadth of coverage is assured by the contributions of an international group of over 30 leading scientists in this field.
Contents list: Elements of chromatin structure: histones, nucleosomes, fibers; DNA structure: implications for chromatin structure and function; Replication and assembly; Promoter potentiation and activation: chromatin structure and transcriptional induction of heat shock genes; Initiation of expression: remodelling genes; Transcription on chromatin templates; Chromatin structure and epigenetic regulation in yeast; Epigenetic regulation in Drosophilia: a conspiracy of silence; Boundaries and domains; Epigenetic regulation in mammalian cells.
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implications for chromatin structure
Histone contributions to the structure of DNA in
Chromatin replication and assembly
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Abd-B antibodies assay assembly associated binding Chem chromatin domains chromatin structure chromatin templates chromo domain cis-regulatory complex core histones core particle derepression dimers disruption DNA methylation DNA replication DNA sequences DNA-binding Drosophila melanogaster elements EMBO enhancer epigenetic euchromatin eukaryotic fibre function GAGA gene expression Genes and Dev genetic genome heterochromatin histone acetylation histone H4 histone octamer HM loci homeotic genes hypersensitive inactivation inactive initiation interactions linker locus mechanism modifiers molecular molecules mouse mutations Natl Acad nuclear nucleosomal templates nucleosome nucleosome core nucleus observed pattern Pc-G phenotype Pho4 PHO5 promoter plasmid Polycomb position effect Proc protein regions regulation regulatory replication fork repression RNA polymerase RNA polymerase III role Saccharomyces cerevisiae silencing silent mating-type loci SIR3 specific strands studies suggest supercoiled synthesis telomeres tion topoisomerase transcribed transcript elongation transcription factor transcriptional activation transcriptionally transgenic vitro vivo X chromosome Xist yeast