Chronic Pain and Addiction
Michael R. Clark, Glenn J. Treisman
Karger Medical and Scientific Publishers, Jan 1, 2011 - Medical - 165 pages
The relationship between chronic pain and addiction Patients with chronic pain understandably seek relief from their distress and discomfort, but many medications that alleviate pain are potentially addictive, and most chronic pain conditions only have a temporary response to opiate analgesic drugs. This volume reviews the fundamental topics that underlie the complex relationships of this controversial domain. The authors review behavioral models and practical methods for understanding and treating chronic pain and addiction including methods to formulate patients with complex comorbidity and screen patients with chronic pain for addictive liability. Finally, the authors describe the current findings from clinical and basic science that illuminate the role of opiates, cannabinoids and ketamine in the treatment of chronic pain. Up to date and comprehensive, this book is relevant to all professionals engaged in the care of patients with chronic pain or addiction and all others interested in these contemporary issues, particularly non-clinicians seeking clarity in the controversy over the best approach to patients with chronic pain.
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aberrant addictive drugs administration alfentanil amygdala analgesia analgesic animal models assessment associated baclofen brain reward brain stimulation reward buprenorphine cancer pain cannabinoids cannabis central chronic noncancer pain chronic pain chronic pain patients Clin J Pain clinical clinicians cocaine comorbidities craving crossover depression dopamine doses double-blind drug abuse drug addiction drug-seeking behavior effects of ketamine efficacy etal evaluation factors fibromyalgia follow-up function Gardner hyperalgesia increased infusion intravenous ketamine Koob GF Medicine methadone mg/kg misuse morphine nabilone neural neurons neuropathic pain Neurosci nicotine NMDA receptor nucleus accumbens opiates opioid abuse opioid analgesics oral Pain and Addiction pain management pain relief Pain Symptom Manage pain syndrome patients receiving patients with chronic Pharmacol physical dependence physicians placebo placebo-controlled Portenoy RK potential predict prescribed opioids prescription problems rats receptor antagonists reinforcement relapse reward circuitry risk self-administration studies substance use disorders Synapse tion treatment of chronic treatment programs ventral tegmental vulnerability