Cingulate Neurobiology and Disease
OUP Oxford, Jun 4, 2009 - Medical - 829 pages
In the past 15 years parts of the cingulate cortex have been activated in thousands of neuroimaging studies and it has become a primary site of interest in structural and functional analyses of many neurological and psychiatric diseases. There are now more then 20 times the number of annual publications that analyse this region than there were 30 years ago. There are many diseases that have an early and direct impact on the cingulate cortex, including, chronic pain and stress syndromes, depression, obsessive-compulsive and attention-deficit/hyperactivity disorders, and neurodegenerative diseases such as schizophrenia, mild cognitive impairment, dementia with Lewy bodies, and Alzheimer's disease. This major new text brings together cutting-edge information on the human cingulate cortex and its diseases as written by the leading authorities, and synthesizes these with other approaches - including neurophysiology and neuroanatomy in experimental animals; mainly in monkeys. The book considers cingulate infrastructure in terms of its cytology, receptor binding and circuitry, including functions such as emotion and autonomic and skeletomotor regulation, pain processing and chronic stress syndromes, cognition, and visuospatial orientation. Cingulate Neurobiology and Disease is a major publication in neuroscience, one that will have a major influence on research for years to come.
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abnormalities activity afferents aMCC amygdala area 24 area 32 associated auditory autonomic basal basal ganglia behavioral Brain Res caudal cells cerebral cerebral cortex Chapter cingulate areas cingulate cortex cingulate gyrus cingulate motor area cingulate region cingulate sulcus circuitry circuits CMAr cognitive Comp Neurol connections correlated cortical cytoarchitectural daMCC depression disease disorder dopamine dorsal dPCC effects emotional fMRI frontal functional imaging GABAA receptor Goldman-Rakic Hoesen human imaging studies impaired inputs interactions involved laminar layer lesions limbic lobe medial prefrontal memory modulation Morecraft neuroimaging neurons Neurosci nociceptive noxious nucleus OCD patients orbitofrontal cortex output pACC Pandya parietal pMCC positron emission tomography posterior cingulate prefrontal cortex premotor primate processing projections PTSD rCBF receptor densities region responses retrosplenial role rostral sACC schizophrenia seizures sensory showed specific stimulation stress structures subregions symptoms task temporal thalamus tion ventral visceral visual Vogt vPCC