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EFFECTS OF BEDREST ON ORCADIAN RHYTHMICITY
CHANGES IN GLUCOSE INSULIN AND GROWTH HORMONE
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20 DAYS POST 42 DAYS 48-hr sampling period 54 of bedrest 56 days 56-DAY BEDREST STUDIES ambulatory and bedrested ambulatory controls ambulatory subjects area represents lights-off associated with bedrest bedrest on circadian bedrest results bedrested subjects blood sampling body temperature cardiotachometer catecholamine circadian rhythms circadian synchrony circulating levels corticosteroid cortisol levels DAYS BED REST days of bedrest decreased diurnal rhythms effect of bedrest effects of prolonged endocrine endocrine and metabolic environment Figure five subjects glucose levels growth hormone heart rate homeostasis hydrocortisone hypoglycemia Integrated daily mean lines represent standard mean daily measured NONEXERCISED parameters parathormone levels Parathyroid Hormone peak PERIODOGRAMS phase angle phase shift photoperiod Plasma ACTH Plasma cortisol Plasma parathormone POST 20 DAYS postbedrest period prolonged bedrest radioimmunoassay reported represents lights-off period rhythm asynchrony rhythmicity schedule steroid stipled area represents subject aged subjects showed summation dial thyroid hormone thyroxine triiodothyronine urinary vertical lines represent