Circular Dichroism: Principles and Applications

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Nina Berova, Koji Nakanishi, Robert Woody
John Wiley & Sons, May 3, 2000 - Science - 877 pages
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Multidisciplinary coverage of circular dichroism's principles, applications, and latest advances

The four years since the publication of the first edition of Circular Dichroism: Principles and Applications have seen a rapid expansion of the field, including new applications, improved understanding of principles, and a growing interest in circular dichroism (CD) among researchers from a wide variety of disciplines. The Second Edition keeps pace with this phenomenal growth with up-to-date contributions from dozens of the world's leading researchers and practitioners in chirality, chemistry, biochemistry, and analytical chemistry, as well as vibrational and luminescence spectroscopy.

With nine entirely new chapters and substantial updates of existing material, Circular Dichroism, Second Edition provides important insight into the immense potential of CD and bridges the gap between theory and practice. The book begins with coverage of historical developments and moves quickly to fascinating reports on recent advances and emerging new fields in CD. New and updated coverage includes:
* VOA theory
* Solid-state CD applications
* Fast time-resolved CD measurements
* A model illustrating how polymers amplify chirality
* Induced CD of polymers
* CD of nucleic acids: nonclassical conformations and modified oligonucleotides
* DNA-drug and DNA-protein interactions
* Applications of CD to important pharmaceutical compounds

Featuring an increased emphasis on biological molecules and extensive applications to organic stereochemistry and biopolymers, Circular Dichroism: Principles and Applications, Second Edition will prove a valuable and frequently consulted reference for organic chemists, biochemists, and medicinal and pharmaceutical chemists.
 

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Contents

An Introduction
1
Theories of the Origin
37
Theoretical Approach To Electronic Optical Activity
55
Vibrational Optical Activity Theory
97
Circular Dichroism of Oriented Molecules
133
Application to Inorganic and Organic Chemistry
159
A Probe for Chirality
185
Chiroptical Luminescence Spectroscopy as a Probe of the Chiralitj Dependent
217
Determination of Conformations and Absolute Configurations
459
A Model for How Polymers Amplify Chiraliry
491
Induced CD or Polymers
521
Application of CD to the Study of Some Cholesteric Mesophase
547
Interpretation
563
Circular Dichroism of Peptides and Proteins
601
Peptide and Protein Conformational Studies with Vibrational
621
From Fundamentals
667

Fast TimeResolved Circular Dichroism Measurements
243
The Octant Rule
261
Circular Dichroism and Chiraliry of Dienes
305
Principles and Applications
337
Applications of the Benzene Sector and Benzene Chirality Rules
397
Products with a Novel Pentacyclic Skeleton as Determined by Theoretical
439
Nonclassical Conformations
719
DNADrug Interactions
741
Stereochemical Analysis at Work
797
Applications of Chiropticat Spectroscopy in the Characterization
819
Index
845
Copyright

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About the author (2000)

NINA BEROVA, PhD, is a Professor and Senior Research Scientist in the Department of Chemistry at Columbia University, New York. She is the North American Editor of the international journal Chirality.

KOJI NAKANISHI, PhD, is Centennial Professor of Chemistry in the Department of Chemistry at Columbia University, New York. He is the recipient of many international awards and the Person of Cultural Merit Award (Japanese government).

ROBERT W. WOODY, PhD, is a Professor in the Department of Biochemistry and Molecular Biology at Colorado State University, Fort Co

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