Cleft Lip and Palate: From Origin to Treatment
Diego F. Wyszynski
Oxford University Press, Aug 1, 2002 - Medical - 548 pages
Majoradvances in the diagnosis and treatment of oral clefts have been made in the past 50 years, and recent genetics and epidemiological studies have led to new theories about the causes of cleft lip and palate. Addressing issues that are relevant to clinicians, researchers and family members, this book is a comprehensive, well-illustrated, and up-to-date account of the many facets of this common disorder. The authors describe the embryological and molecular mechanisms of cleft causation, present and illustrate the genetic and epidemiological methods used to identify risk factors for oral clefts, and describe treatments by the various professionals of the cleft team. A section is also devoted to the integration of research findings into public health practice, including ethical and financial considerations. The book draws together such diverse disciplines as craniofacial development, gene mapping, epidemiology, medicine, ethics, health economics, and health policy and management, and it will be an invaluable reference work.
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abnormalities allele analysis arch assessment associated bilateral birth defects bone grafting case-control study Caucasian cells child children with cleft cholesteatoma chromosome CL/P CL/P and CP cleft lip Cleft Palate Craniofac clinical closure congenital controls Czeizel dental disease effect embryos etiology evaluation exposure facial clefts folate folic acid gene genome genotype growth factor Hum Genet human individuals infants interaction isolated cleft linkage lip and palate loci locus malformations mandibular marker maternal maxilla maxillary mice mothers mouse nasal neural normal oral clefts oral-facial clefts orofacial clefts orthodontic otitis media outcome parents patients Pediatr pharyngeal pharyngeal flap Plast Plast Reconstr Surg population population-based pregnancy prevalence primary probands receptor repair reported risk Robin sequence secondary palate soft palate speech surgery surgical syndrome teratogens Teratology TGFA tion tissue treatment tube twins tympanostomy tubes velopharyngeal vitamin vitamin B6