Clinical Aspects and Laboratory. Iron Metabolism, Anemias: Concepts in the anemias of malignancies and renal and rheumatoid diseases
Springer Science & Business Media, Feb 1, 2012 - Medical - 198 pages
Iron is essential for most forms of life, including humans. On the other hand, iron is also potentially toxic. Therefore, the control of iron metabolism and maintenance of iron hemostasis is an crucial part of many aspects of human health and disease. Iron deficiency anemia is one of the most common diseases worldwide, but there are also anemias associated with chronic diseases, and other acquired or hereditary defects. Understanding the control of iron metabolism is furthermore important for understanding diseases of iron overload, like hemochromatosis. This booklet is designed for physicians, clinical lab personnel and medical students. It gives an overview about the principles of regulation of iron metabolism and erythropoiesis. In addition, the various disturbances of iron metabolism and the associated clinical findings are described. Special focus lies on the differential diagnosis of the disorders, and the approaches of therapy. Finally, a comprehensive schedule of tests is included available for the determination of iron metabolism-related parameters in serum/plasma and blood, with indication of methodologies applied and reference ranges.
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Diagnosis of Disturbances of Iron Metabolism
Iron Deficiency Diagnosis and Therapy
Disturbances of Iron Distribution and Hypochromic Anemias
Disturbances of Iron Utilization
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anemia of chronic antibodies binding body’s bone marrow caused chronic disease chronic inflammations Clin clinical cytokines detected determination diagnosis dialysis patients differentiation disturbances of iron elevated erythro erythrocytes erythroid erythropoietin Fe2+ Fe3+ ferritin ferritin values folic acid deficiency functional iron deficiency g/dL haptoglobin hematocrit hematologic hemochromatosis hemolysis hemolytic hepcidin homocysteine hypochromic i.v. iron immunoassay increased iron indicator infections inflammatory intestinal intracellular iron concentration iron deficiency anemia iron distribution iron metabolism iron overload iron requirement iron reserves iron stores iron supply iron therapy iron-binding capacity isoferritins liver macrocytic anemia macrophages malignant maturation MCHC methods mg/L Myelodysplastic syndrome ng/mL normal normocytic parameters red blood cells red cells reduced Reference Range renal anemia result Ret-Hb reticulocyte count reticulocyte production index rhu-EPO serum ferritin soluble transferrin receptor sTfR storage iron syndrome synthesis Table thalassemia TIBC tion transferrin receptor transferrin saturation transfusions transport tumor anemias