Clinical Cases in Primary Immunodeficiency Diseases: A Problem-Solving Approach

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Asghar Aghamohammadi, Nima Rezaei
Springer Science & Business Media, Dec 13, 2012 - Medical - 380 pages
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Primary immunodeficiency diseases (PIDs) are a heterogeneous group of inherited disorders characterized by different defects in the development and function of the immune system. This book aims to increase the clinical awareness and knowledge of practicing clinicians regarding the diagnosis and management of PIDs. In order to achieve this goal, about 90 cases drawn from real life are presented, along with approximately 300 related questions. The selected case reports are the result of the invaluable cooperation of more than 40 scientists in the field of immunodeficiency. They focus both on the presenting features of patients with PIDs and on the required further investigation and management. Each of the numbered cases is followed by the questions, their answers, and additional discussion. Each question focuses on a particular aspect of the PID under consideration, and the topics covered include clinical diagnosis, laboratory findings, molecular mechanisms, and therapy.

 

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Contents

1 Recurrent Infections
1
2 Combined T and B Cell Immunodeficiencies
76
3 Predominantly Antibody Deficiency
113
4 Disorders of Phagocytic Cells
193
5 Immune Dysregulation Diseases
233
6 Defects in Innate Immunity Receptors and Signaling Components
278
7 Autoinflammatory Disorders
309
8 Complement Deficiencies
325
9 Other WellDefined Immunodeficiency Syndromes
342
Index
369
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