Clinical Epidemiology: The Study of the Outcome of Illness, Volume 27; Volume 1996
Examining the principles and methods of research on the evaluation of factors affecting the outcome of illness, this volume emphasizes diagnostic and therapeutic interventions--the factors most readily modified by health care providers. The author discusses various ways of structuring observations on patient groups, and appraises the nature and strength of inferences drawn from those observations. Weiss also demonstrates how the results of this type of research--clinical epidemiologic research--can be incorporated into the decision-making process utilized in clinical medicine.
The Second edition differs from the earlier one in a number of respects. It now employs a broader frame of reference, which includes studies such as those of adverse drug effects that use multipurpose computerized databases, and an expanded, explanation of the structure of evidence for drawing inferences, particularly evidence pertaining to the efficacy of testing. Examples have been modernized and replaced with more recent experimental results throughout the text, while decision analysis has been de-emphasized. The book's underlying theme, however, remains the same: the resources available to health care are finite and, through properly conducted research, the most efficient and safest ways of using these resources can and should be identified.
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Measuring Their Role
Randomized Controlled Trials
Natural History of Illness
and Analysis of Clinical Epidemiologic Research
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acute adjusted adverse effect analysis antihypertensive artery assess associated bias blood pressure breast cancer cardiac case-control study characteristics chest pain cimetidine clinical epidemiology cohort colorectal cancer compared condition confounding control group Coronary Drug Project criteria death detect determine diabetic diagnosis diazepam difference disease domized endometrial cancer endometriosis endpoint estimate estrogen example factors fecal occult blood follow-up frequency given heart failure hospital hypertensive identified incidence influence intervention investigators JAMA Lancet lidocaine measure monitored mortality rates myocardial infarction natural history negative NEngl JMed nonrandomized studies number of subjects obtained occurrence oligohydramnios oral contraceptives ovarian cancer period persons placebo population positive possible predictive value pregnancy present prior proportion prostate cancer randomized controlled trial randomized trial received the therapy relative renal retinopathy risk screening test serum specificity stage survival symptoms therapeutic tients tion transplant treated treatment groups tumor untreated vaccine valid ventricular Weiss women