Clinical Nephrotoxins: Renal Injury from Drugs and Chemicals

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Marc E. de Broe, George A. Porter, William M. Bennett, G.A. Verpooten
Springer Science & Business Media, May 31, 2003 - Medical - 712 pages
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To you the reader, the joy of discovery begins, for We continue in our goal of providing a text which us the job is done. In this edition, we have corrected is useful, not only to the clinician, but of equal interest past deficiencies, added new topics, expanded infor- to the investigator. The selection of content has been mation regarding the pediatric age group, provided directed at topics of current interest rather than those up to date (March 2003) references, while remaining of historic contribution. We have stressed the cont- true to our concept of a multi-national author book. bution of cell biology and pathophysiology, were it We continue to believe that scientific information is an exists, believing it provides both a better understa- international commodity whose interpretation and ap- ing of toxic injury when known, and a rational dir- plication are strongly influenced by both the cultural tion for therapy and prevention. and ethnic background of the observer. The oppor- nity to share in the rich diversity of the international We are encouraged by the accumulation of rec- scientific community remains a fundamental goal of nized risk factors, which allow pre-treatment strati- this endeavor. To participate as equals leads to mu- cation of our patients’ relative risk and allow us to - tual respect and peer appreciation. The sharing of in- cus our preventative techniques on the individuals tellectual resources fostered by this effort should and most likely to gain the greatest benefit.
 

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Contents

Renal handling of drugs and xenobiotics
21
Pharmacovigilance
47
Introduction ____________________________________________________________
78
7
81
The isolated perfused rat kidney __________________________________________
85
Methods to evaluate the renal microcirculation _____________________________
95
nephrotoxic mechanisms
115
B SPECIFIC DRUGS 149
148
Anesthetic agents
373
Illicit drug abuse 383
382
Calcineurin inhibitors and sirolimus
403
interleukins interferons and the OKT3 monoclonal antibody
459
Lead nephropathy
495
Cadmiuminduced renal effects
507
Mercuryinduced renal effects
531
Hydrocarbons siliconcontaining compounds and pesticides
545

Betalactam antibiotics
171
Amphotericin B
199
Sulfonamides sulfadiazine trimethoprimsulfamethoxazole pentamidine
223
06
230
Antiviral agents 249
248
Analgesics and 5aminosalicylic acid
263
Nonsteroidal antiinflammatory drugs
279
Gold salts Dpenicillamine and allopurinol
307
Angiotensin I converting enzyme inhibitors and angiotensin II receptor antagonists
325
Diuretics
339
Anticancer drugs
353
Lithiuminduced renal effects
559
Aristolochic acid nephropathy after Chinese herb remedies
579
Balkan endemic nephropathy
587
Nephrotoxins in Africa
603
Paraphenylene diamine hair dye poisoning
611
PREVENTION
619
Pharmacological aspects of nephrotoxicity
657
Drug dosage in renal failure
667
LIST OF ABBREVIATIONS 681
680
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About the author (2003)

Porter graduated from the University of California at Davis in the field of small animal medicine. He helped found the Emergency pet Clinic of South Bay, Inc. in Torrance, CA.

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