Clinical Pharmacology of Sleep

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S.R. Pandi-Perumal, J.M. Monti
Springer Science & Business Media, Feb 16, 2006 - Medical - 239 pages
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From the emergence of clinical sleep medicine marked by the establishment of the harbinger Stanford Sleep Disorders Clinic in the mid 1970s, offspring sleep dis- ders clinics and centers have grown exponentially with the recognition of the unmet diagnostic and treatment needs of the reservoir of patients suffering from sy- toms of what are now recognized and classi?ed as the nosology of human sleep disorders. Important in the growing armamentarium of treatment options for the sleep practitioner are both traditional and newer pharmacological agents, including over-the-counter, non-traditional, and prescription types, that are all used to treat, sometimes adjunctively, most clinically recognized sleep disorders. Although there are numerous academic treatises and reviews dealing with in- vidual treatment alternatives for the diversity of recognized sleep disorders, no one comprehensive resource, extant, has dealt with pharmacological treatment options and strategies for the major human sleep disorders associated with a panoply of symptomatic conditions. The present volume and its series of chapters individually focusing on a range of human conditions, from pediatric sleep disorders to sle- relateddisordersofindividualssufferingfromAlzheimer’sdementia,uniquelycover the wide range of human medical conditions amenable to thoughtfully sleep-related applied drug therapy. The Editors have brought together a superb group of internationally respected sleep clinicians, and researchers, that provide state-of-the-art analysis of the current basic and clinical perspective regarding the most common sleep disorders that are amenable to pharmacological treatment. In each chapter the authors outline a th- oughhistoricalbackgroundoftheparticulardisorderandreviewthebasicpre-clinical studies leading to current treatment options.
 

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Contents

Primary and secondary insomnia
1
diagnosis and treatment
11
Neuropharmacology of obstructive sleep apnea and central apnea
21
a new view at the beginning of the second millennium
43
Sleep disturbances in restless legs syndrome RLS and periodic limb movements PLM
61
Sleep disturbances in anxiety disorders
81
Sleep disturbances in affective disorders
101
Sleep disturbance in schizophrenia
125
Assessment and treatment of sleep disturbances in aged population
153
Sleep disturbances in Alzheimers disease
173
Sleep disturbance during menopause
183
Chronopharmacology and its implications to the pharmacology of sleep
197
Overview of currently available benzodiazepine and nonbenzodiazepine hypnotics
207
Rebound and withdrawal with benzodiazepine and nonbenzodiazepine hypnotic medication
225
Index
235
Copyright

Clinical pharmacology of sleep disturbances in children and adolescents
133

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